Generalized pustular psoriasis flare

A generalized pustular psoriasis flare is an acute, potentially life-threatening clinical exacerbation of generalized pustular psoriasis, a rare autoinflammatory skin disorder It primarily affects the integumentary system in adults and pediatric patients, manifesting as the rapid, widespread eruption of painful, sterile, neutrophilic pustules coalescing over intensely erythematous and edematous skin This flare state is driven by severe innate immune hyperactivation—predominantly via dysregulatio...

A generalized pustular psoriasis flare is an acute, potentially life-threatening clinical exacerbation of generalized pustular psoriasis, a rare autoinflammatory skin disorder

It primarily affects the integumentary system in adults and pediatric patients, manifesting as the rapid, widespread eruption of painful, sterile, neutrophilic pustules coalescing over intensely erythematous and edematous skin This flare state is driven by severe innate immune hyperactivation—predominantly via dysregulation of the interleukin-36 signaling pathway—and frequently induces high fever, profound fatigue, leukocytosis, and systemic inflammation capable of progressing to hemodynamic ins...

It primarily affects the integumentary system in adults and pediatric patients, manifesting as the rapid, widespread eruption of painful, sterile, neutrophilic pustules coalescing over intensely erythematous and edematous skin

This flare state is driven by severe innate immune hyperactivation—predominantly via dysregulation of the interleukin-36 signaling pathway—and frequently induces high fever, profound fatigue, leukocytosis, and systemic inflammation capable of progressing to hemodynamic instability or multisystem organ failure