Hematologic malignancy

A hematologic malignancy is a broad clinical category encompassing cancers that originate in blood-forming tissues, such as the bone marrow, or in cells of the immune and lymphatic systems

A hematologic malignancy is a broad clinical category encompassing cancers that originate in blood-forming tissues, such as the bone marrow, or in cells of the immune and lymphatic systems These neoplasms affect pediatric and adult populations and primarily include leukemias, lymphomas, and plasma cell neoplasms such as multiple myeloma, as well as related conditions like myelodysplastic syndromes and myeloproliferative neoplasms

These neoplasms affect pediatric and adult populations and primarily include leukemias, lymphomas, and plasma cell neoplasms such as multiple myeloma, as well as related conditions like myelodysplastic syndromes and myeloproliferative neoplasms

Pathophysiologically, they are characterized by the clonal expansion, impaired differentiation, and uncontrolled proliferation of abnormal hematopoietic or lymphoid precursors Clinically, this marrow infiltration and tissue disruption often result in cytopenias, impaired immune function, generalized lymphadenopathy, organomegaly, and systemic symptoms

Pathophysiologically, they are characterized by the clonal expansion, impaired differentiation, and uncontrolled proliferation of abnormal hematopoietic or lymphoid precursors

Clinically, this marrow infiltration and tissue disruption often result in cytopenias, impaired immune function, generalized lymphadenopathy, organomegaly, and systemic symptoms