Heterotopic ossification

Heterotopic ossification is a musculoskeletal pathology characterized by the abnormal formation of mature, lamellar bone within extraskeletal soft tissues such as skeletal muscle, tendons, and ligaments where bone does not normally exist It most commonly develops as an acquired complication following significant musculoskeletal trauma, orthopedic surgery, severe burns, or central nervous system injuries like traumatic brain injury and spinal cord trauma

Heterotopic ossification is a musculoskeletal pathology characterized by the abnormal formation of mature, lamellar bone within extraskeletal soft tissues such as skeletal muscle, tendons, and ligaments where bone does not normally exist

It most commonly develops as an acquired complication following significant musculoskeletal trauma, orthopedic surgery, severe burns, or central nervous system injuries like traumatic brain injury and spinal cord trauma

It most commonly develops as an acquired complication following significant musculoskeletal trauma, orthopedic surgery, severe burns, or central nervous system injuries like traumatic brain injury and spinal cord trauma Pathophysiologically driven by an inappropriate osteogenic differentiation of mesenchymal progenitor cells often spurred by local inflammation, the condition typically presents with localized pain, swelling, erythema, progressive joint stiffness, and a decreased range of motion t...

Pathophysiologically driven by an inappropriate osteogenic differentiation of mesenchymal progenitor cells often spurred by local inflammation, the condition typically presents with localized pain, swelling, erythema, progressive joint stiffness, and a decreased range of motion that can advance to complete joint ankylosis