Hormone receptor positive, HER2-positive metastatic breast cancer

Hormone receptor-positive, HER2-positive metastatic breast cancer is an advanced stage IV malignancy originating in the mammary epithelium that has disseminated beyond the breast and regional lymph nodes to distant organs or tissues

This distinct molecular subtype is characterized by the co-expression of estrogen and/or progesterone receptors alongside the amplification of the ERBB2 gene or overexpression of the human epidermal growth factor receptor 2 protein

This distinct molecular subtype is characterized by the co-expression of estrogen and/or progesterone receptors alongside the amplification of the ERBB2 gene or overexpression of the human epidermal growth factor receptor 2 protein

This distinct molecular subtype is characterized by the co-expression of estrogen and/or progesterone receptors alongside the amplification of the ERBB2 gene or overexpression of the human epidermal growth factor receptor 2 protein The dual activation of intracellular steroid hormone signaling and HER2-driven receptor tyrosine kinase pathways produces aggressive cellular proliferation, survival signaling, and complex biological cross-talk that influences therapeutic sensitivity

The dual activation of intracellular steroid hormone signaling and HER2-driven receptor tyrosine kinase pathways produces aggressive cellular proliferation, survival signaling, and complex biological cross-talk that influences therapeutic sensitivity