Hypercortisolism

Hypercortisolism is an endocrine disorder characterized by prolonged, inappropriate systemic exposure to excessive levels of glucocorticoids It affects multiple organ systems and can arise from exogenous glucocorticoid administration or endogenous causes, which are further classified as ACTH-dependent (such as pituitary or ectopic ACTH-secreting tumors) or ACTH-independent (such as autonomous adrenal cortical adenomas or hyperplasia)

Hypercortisolism is an endocrine disorder characterized by prolonged, inappropriate systemic exposure to excessive levels of glucocorticoids Pathophysiologically, the sustained excess of circulating cortisol disrupts metabolic, vascular, bone, and immune homeostasis Clinically, it manifests as central adiposity, facial plethora, proximal muscle weakness, purple cutaneous striae, osteoporosis, hypertension, and glucose intolerance

It affects multiple organ systems and can arise from exogenous glucocorticoid administration or endogenous causes, which are further classified as ACTH-dependent (such as pituitary or ectopic ACTH-secreting tumors) or ACTH-independent (such as autonomous adrenal cortical adenomas or hyperplasia)

Pathophysiologically, the sustained excess of circulating cortisol disrupts metabolic, vascular, bone, and immune homeostasis Clinically, it manifests as central adiposity, facial plethora, proximal muscle weakness, purple cutaneous striae, osteoporosis, hypertension, and glucose intolerance

Clinically, it manifests as central adiposity, facial plethora, proximal muscle weakness, purple cutaneous striae, osteoporosis, hypertension, and glucose intolerance