Immunoglobulin A nephropathy

Immunoglobulin A nephropathy is a chronic autoimmune renal disease and the most common primary glomerulonephritis worldwide It is pathologically characterized by the deposition of galactose-deficient immunoglobulin A1–containing immune complexes in the glomerular mesangium, triggering mesangial proliferation, local inflammation, and progressive glomerular injury

Immunoglobulin A nephropathy is a chronic autoimmune renal disease and the most common primary glomerulonephritis worldwide Clinically, affected individuals typically present with microscopic or episodic gross hematuria—often concurrent with upper respiratory tract infections—along with varying degrees of proteinuria and hypertension

It is pathologically characterized by the deposition of galactose-deficient immunoglobulin A1–containing immune complexes in the glomerular mesangium, triggering mesangial proliferation, local inflammation, and progressive glomerular injury

It is pathologically characterized by the deposition of galactose-deficient immunoglobulin A1–containing immune complexes in the glomerular mesangium, triggering mesangial proliferation, local inflammation, and progressive glomerular injury The condition can affect patients of all ages, most frequently young adults, and may insidiously progress over years to chronic kidney disease and end-stage renal disease

Clinically, affected individuals typically present with microscopic or episodic gross hematuria—often concurrent with upper respiratory tract infections—along with varying degrees of proteinuria and hypertension The condition can affect patients of all ages, most frequently young adults, and may insidiously progress over years to chronic kidney disease and end-stage renal disease

Clinically, affected individuals typically present with microscopic or episodic gross hematuria—often concurrent with upper respiratory tract infections—along with varying degrees of proteinuria and hypertension