Immunoglobulin deficiency

**Immunoglobulin deficiency** is a state of humoral immune dysfunction characterized by abnormally low serum levels of one or more antibody classes—such as IgG, IgA, or IgM—or an inability to produce functional specific antibodies Pathophysiologically, impaired B-cell maturation, plasma cell differentiation, or excessive antibody loss compromises humoral pathogen neutralization and opsonization

**Immunoglobulin deficiency** is a state of humoral immune dysfunction characterized by abnormally low serum levels of one or more antibody classes—such as IgG, IgA, or IgM—or an inability to produce functional specific antibodies

It can arise across all age groups as a primary, congenital inborn error of immunity—including common variable immunodeficiency or selective isotype deficiencies—or secondary to hematologic malignancies, protein-losing states, or immunosuppressive therapies Clinically, affected patients exhibit heightened susceptibility to recurrent, persistent, or severe sinopulmonary and gastrointestinal infections, predominantly caused by encapsulated bacteria, and face increased risks of bronchiectasis, auto...

It can arise across all age groups as a primary, congenital inborn error of immunity—including common variable immunodeficiency or selective isotype deficiencies—or secondary to hematologic malignancies, protein-losing states, or immunosuppressive therapies Clinically, affected patients exhibit heightened susceptibility to recurrent, persistent, or severe sinopulmonary and gastrointestinal infections, predominantly caused by encapsulated bacteria, and face increased risks of bronchiectasis, auto...

It can arise across all age groups as a primary, congenital inborn error of immunity—including common variable immunodeficiency or selective isotype deficiencies—or secondary to hematologic malignancies, protein-losing states, or immunosuppressive therapies Pathophysiologically, impaired B-cell maturation, plasma cell differentiation, or excessive antibody loss compromises humoral pathogen neutralization and opsonization

Clinically, affected patients exhibit heightened susceptibility to recurrent, persistent, or severe sinopulmonary and gastrointestinal infections, predominantly caused by encapsulated bacteria, and face increased risks of bronchiectasis, autoimmune phenomena, and lymphoproliferative disorders