Kidney transplant rejection

Kidney transplant rejection is an immunologic complication occurring in renal allograft recipients where the host immune system identifies donor human leukocyte antigens as foreign and mounts an alloimmune attack Clinically, rejection manifests as acute or progressive graft dysfunction characterized by elevated serum creatinine, reduced urine output, proteinuria, and characteristic histopathologic features including tubulitis, interstitial inflammation, or microvascular capillaritis

Kidney transplant rejection is an immunologic complication occurring in renal allograft recipients where the host immune system identifies donor human leukocyte antigens as foreign and mounts an alloimmune attack

It primarily compromises the renal system and allograft vasculature, categorized temporally and mechanistically into hyperacute, acute, or chronic forms driven by T-cell-mediated pathways, donor-specific antibody-mediated injury, or mixed mechanisms Clinically, rejection manifests as acute or progressive graft dysfunction characterized by elevated serum creatinine, reduced urine output, proteinuria, and characteristic histopathologic features including tubulitis, interstitial inflammation, or mi...

Clinically, rejection manifests as acute or progressive graft dysfunction characterized by elevated serum creatinine, reduced urine output, proteinuria, and characteristic histopathologic features including tubulitis, interstitial inflammation, or microvascular capillaritis