Indication

Latent late syphilis

Late latent syphilis is an asymptomatic stage of systemic infection caused by the spirochete bacterium *Treponema pallidum*, acquired more than one year prior (or more than two years by World Health Organization criteria). Read more about Latent late syphilis

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About Latent late syphilis.

Late latent syphilis is an asymptomatic stage of systemic infection caused by the spirochete bacterium *Treponema pallidum*, acquired more than one year prior (or more than two years by World Health Organization criteria).

It affects sexually active adolescents and adults, as well as infants through vertical transmission, and is identified solely by persistent treponemal and non-treponemal serologic reactivity in the absence of active clinical signs or symptoms of primary, secondary, or tertiary disease.

Pathophysiologically, the bacteria remain sequestered in host tissues under partial immune control, presenting a lower risk of sexual transmission than early-stage infection but carrying potential long-term risk of progression to tertiary complications or congenital transmission during pregnancy.

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