Malignant neoplasm of gastroesophageal junction

A malignant neoplasm of the gastroesophageal junction is an aggressive cancer arising at the anatomical transition zone between the distal esophagus and the gastric cardia of the stomach

A malignant neoplasm of the gastroesophageal junction is an aggressive cancer arising at the anatomical transition zone between the distal esophagus and the gastric cardia of the stomach Predominantly affecting adults—with a higher incidence in older males and individuals with chronic gastroesophageal reflux disease, obesity, or Barrett esophagus—the vast majority of these tumors are adenocarcinomas Pathophysiologically, persistent mucosal inflammation and acid-induced intestinal metaplasia lead...

Predominantly affecting adults—with a higher incidence in older males and individuals with chronic gastroesophageal reflux disease, obesity, or Barrett esophagus—the vast majority of these tumors are adenocarcinomas Pathophysiologically, persistent mucosal inflammation and acid-induced intestinal metaplasia lead to dysplastic transformation, local transmural invasion, and frequent lymphatic dissemination Patients commonly present with progressive dysphagia, unintentional weight loss, retrosterna...

Predominantly affecting adults—with a higher incidence in older males and individuals with chronic gastroesophageal reflux disease, obesity, or Barrett esophagus—the vast majority of these tumors are adenocarcinomas

Pathophysiologically, persistent mucosal inflammation and acid-induced intestinal metaplasia lead to dysplastic transformation, local transmural invasion, and frequent lymphatic dissemination

Patients commonly present with progressive dysphagia, unintentional weight loss, retrosternal pain, early satiety, and anemia secondary to chronic occult blood loss