Indication

Malignant paraganglioma

Malignant paraganglioma is a rare neuroendocrine neoplasm arising from extra-adrenal chromaffin or non-chromaffin neural crest tissue within the sympathetic or parasympathetic nervous systems. Read more about Malignant paraganglioma

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WELIREG (belzutifan)

ANTINEOPLASTIC - HYPOXIA INDUCIBLE FACTOR (HIF) INHIBITORS·RENAL CELL CARCINOMA·+3

Merck Sharp & Dohme

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About Malignant paraganglioma.

Malignant paraganglioma is a rare neuroendocrine neoplasm arising from extra-adrenal chromaffin or non-chromaffin neural crest tissue within the sympathetic or parasympathetic nervous systems.

Pathophysiologically, malignancy is defined by the presence of distant metastases in non-chromaffin tissues where paraganglionic cells are normally absent, most frequently affecting bones, regional lymph nodes, the liver, and lungs.

Clinically, these tumors can develop in adults or children and may be sporadic or linked to germline mutations, such as in the succinate dehydrogenase genes.

Sympathetic lesions typically produce excessive catecholamines leading to paroxysmal hypertension, headaches, diaphoresis, and tachycardia, whereas parasympathetic variants usually arise in the head and neck and predominantly present with painless local masses or cranial nerve deficits.

nih.gov
Malignant paraganglioma is a rare neuroendocrine neoplasm arising from extra-adrenal chromaffin or non-chromaffin neural crest tissue within the sympathetic or parasympathetic nervous systems Sympathetic lesions typically produce excessive catecholamines leading to paroxysmal hypertension, headaches, diaphoresis, and tachycardia, whereas parasympathetic variants usually arise in the head and neck and predominantly present with painless local masses or cranial nerve deficits
nih.gov
Malignant paraganglioma is a rare neuroendocrine neoplasm arising from extra-adrenal chromaffin or non-chromaffin neural crest tissue within the sympathetic or parasympathetic nervous systems Pathophysiologically, malignancy is defined by the presence of distant metastases in non-chromaffin tissues where paraganglionic cells are normally absent, most frequently affecting bones, regional lymph nodes, the liver, and lungs
nih.gov
Malignant paraganglioma is a rare neuroendocrine neoplasm arising from extra-adrenal chromaffin or non-chromaffin neural crest tissue within the sympathetic or parasympathetic nervous systems
mdpi.com
Malignant paraganglioma is a rare neuroendocrine neoplasm arising from extra-adrenal chromaffin or non-chromaffin neural crest tissue within the sympathetic or parasympathetic nervous systems Clinically, these tumors can develop in adults or children and may be sporadic or linked to germline mutations, such as in the succinate dehydrogenase genes
nih.gov
Pathophysiologically, malignancy is defined by the presence of distant metastases in non-chromaffin tissues where paraganglionic cells are normally absent, most frequently affecting bones, regional lymph nodes, the liver, and lungs
nih.gov
Pathophysiologically, malignancy is defined by the presence of distant metastases in non-chromaffin tissues where paraganglionic cells are normally absent, most frequently affecting bones, regional lymph nodes, the liver, and lungs Clinically, these tumors can develop in adults or children and may be sporadic or linked to germline mutations, such as in the succinate dehydrogenase genes
columbiasurgery.org
Pathophysiologically, malignancy is defined by the presence of distant metastases in non-chromaffin tissues where paraganglionic cells are normally absent, most frequently affecting bones, regional lymph nodes, the liver, and lungs
mayoclinic.org
Clinically, these tumors can develop in adults or children and may be sporadic or linked to germline mutations, such as in the succinate dehydrogenase genes Sympathetic lesions typically produce excessive catecholamines leading to paroxysmal hypertension, headaches, diaphoresis, and tachycardia, whereas parasympathetic variants usually arise in the head and neck and predominantly present with painless local masses or cranial nerve deficits

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