Indication

Malignant pheochromocytoma

Malignant pheochromocytoma is a rare neuroendocrine cancer originating from the chromaffin cells of the adrenal medulla, distinguished from benign forms by metastasis to tissues that normally lack chromaffin cells, such as regional lymph nodes, bone, liver, and lungs. Read more about Malignant pheochromocytoma

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WELIREG (belzutifan)

ANTINEOPLASTIC - HYPOXIA INDUCIBLE FACTOR (HIF) INHIBITORS·RENAL CELL CARCINOMA·+3

Merck Sharp & Dohme

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About Malignant pheochromocytoma.

Primarily affecting the endocrine, cardiovascular, and sympathetic nervous systems, this malignancy frequently produces excessive catecholamines like epinephrine, norepinephrine, and dopamine.

Pathophysiologically, sustained or paroxysmal hypersecretion of these hormones manifests clinically as severe, refractory hypertension, episodic headaches, diaphoresis, palpitations, and elevated risk of end-organ cardiovascular complications.

While it most commonly presents sporadically in adults, a notable proportion of cases are associated with hereditary germline alterations, particularly mutations involving the succinate dehydrogenase complex.

nih.gov
Malignant pheochromocytoma is a rare neuroendocrine cancer originating from the chromaffin cells of the adrenal medulla, distinguished from benign forms by metastasis to tissues that normally lack chromaffin cells, such as regional lymph nodes, bone, liver, and lungs While it most commonly presents sporadically in adults, a notable proportion of cases are associated with hereditary germline alterations, particularly mutations involving the succinate dehydrogenase complex
nih.gov
Malignant pheochromocytoma is a rare neuroendocrine cancer originating from the chromaffin cells of the adrenal medulla, distinguished from benign forms by metastasis to tissues that normally lack chromaffin cells, such as regional lymph nodes, bone, liver, and lungs While it most commonly presents sporadically in adults, a notable proportion of cases are associated with hereditary germline alterations, particularly mutations involving the succinate dehydrogenase complex
clevelandclinic.org
Malignant pheochromocytoma is a rare neuroendocrine cancer originating from the chromaffin cells of the adrenal medulla, distinguished from benign forms by metastasis to tissues that normally lack chromaffin cells, such as regional lymph nodes, bone, liver, and lungs
nih.gov
Primarily affecting the endocrine, cardiovascular, and sympathetic nervous systems, this malignancy frequently produces excessive catecholamines like epinephrine, norepinephrine, and dopamine Pathophysiologically, sustained or paroxysmal hypersecretion of these hormones manifests clinically as severe, refractory hypertension, episodic headaches, diaphoresis, palpitations, and elevated risk of end-organ cardiovascular complications
centerwatch.com
Primarily affecting the endocrine, cardiovascular, and sympathetic nervous systems, this malignancy frequently produces excessive catecholamines like epinephrine, norepinephrine, and dopamine
cancer.gov
Pathophysiologically, sustained or paroxysmal hypersecretion of these hormones manifests clinically as severe, refractory hypertension, episodic headaches, diaphoresis, palpitations, and elevated risk of end-organ cardiovascular complications
mayoclinic.org
Pathophysiologically, sustained or paroxysmal hypersecretion of these hormones manifests clinically as severe, refractory hypertension, episodic headaches, diaphoresis, palpitations, and elevated risk of end-organ cardiovascular complications

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