Methanol poisoning

Methanol poisoning is an acute, potentially life-threatening toxicological emergency resulting from the ingestion, inhalation, or transdermal absorption of methanol, commonly found in adulterated alcohol, windshield washer fluid, and industrial solvents Hallmark clinical and laboratory features include severe high anion gap metabolic acidosis, elevated serum osmolal gap, optic disc hyperemia, blurred vision or irreversible blindness, putaminal necrosis, seizures, coma, and multi-organ failure

Methanol poisoning is an acute, potentially life-threatening toxicological emergency resulting from the ingestion, inhalation, or transdermal absorption of methanol, commonly found in adulterated alcohol, windshield washer fluid, and industrial solvents Toxicity is primarily driven by hepatic metabolism via alcohol dehydrogenase into formaldehyde and subsequently formic acid, which inhibits mitochondrial cytochrome c oxidase and induces cellular hypoxia The condition predominantly affects the ce...

Toxicity is primarily driven by hepatic metabolism via alcohol dehydrogenase into formaldehyde and subsequently formic acid, which inhibits mitochondrial cytochrome c oxidase and induces cellular hypoxia

The condition predominantly affects the central nervous system, eyes, and metabolic equilibrium, typically manifesting after an asymptomatic latent period of 6 to 36 hours