Neonatal seizure

A neonatal seizure is a transient episode of neurological dysfunction caused by abnormal, excessive, or synchronous neuronal discharges within the immature central nervous system during the neonatal period, defined as the first 28 days of life in full-term infants or up to 44 weeks postmenstrual age in preterm infants Clinically, they are categorized as electroclinical or electrographic-only events, frequently presenting as focal clonic or tonic motor activity, subtle automatisms, or autonomic f...

Pathophysiologically, these events stem from developmental imbalances between neuroexcitation and inhibition, often precipitated by acute provoked insults such as hypoxic-ischemic encephalopathy, stroke, intracranial hemorrhage, metabolic disturbances, central nervous system infections, or underlying genetic channelopathies and brain malformations

Pathophysiologically, these events stem from developmental imbalances between neuroexcitation and inhibition, often precipitated by acute provoked insults such as hypoxic-ischemic encephalopathy, stroke, intracranial hemorrhage, metabolic disturbances, central nervous system infections, or underlying genetic channelopathies and brain malformations Clinically, they are categorized as electroclinical or electrographic-only events, frequently presenting as focal clonic or tonic motor activity, subt...

Clinically, they are categorized as electroclinical or electrographic-only events, frequently presenting as focal clonic or tonic motor activity, subtle automatisms, or autonomic fluctuations rather than generalized convulsions