Non-squamous non-small cell lung cancer (NSCLC) with high c-Met protein overexpression

Non-squamous non-small cell lung cancer (NSCLC) with high c-Met protein overexpression is a biomarker-defined subtype of epithelial lung malignancy that predominantly encompasses adenocarcinomas and large cell carcinomas

Non-squamous non-small cell lung cancer (NSCLC) with high c-Met protein overexpression is a biomarker-defined subtype of epithelial lung malignancy that predominantly encompasses adenocarcinomas and large cell carcinomas

Pathophysiologically, the condition is defined by abundant cell-surface density of the c-Met receptor tyrosine kinase—commonly established by immunohistochemistry demonstrating strong membrane staining in a substantial majority of malignant cells—driven by transcriptional upregulation, autocrine signaling, or genomic alterations This elevated receptor expression promotes sustained oncogenic signaling through downstream proliferative and anti-apoptotic cascades, often conferring aggressive tumor ...

Pathophysiologically, the condition is defined by abundant cell-surface density of the c-Met receptor tyrosine kinase—commonly established by immunohistochemistry demonstrating strong membrane staining in a substantial majority of malignant cells—driven by transcriptional upregulation, autocrine signaling, or genomic alterations This elevated receptor expression promotes sustained oncogenic signaling through downstream proliferative and anti-apoptotic cascades, often conferring aggressive tumor ...

This elevated receptor expression promotes sustained oncogenic signaling through downstream proliferative and anti-apoptotic cascades, often conferring aggressive tumor behavior, therapeutic resistance, and a poorer overall clinical prognosis