Pemphigus vulgaris

Pemphigus vulgaris is a rare, severe, chronic autoimmune mucocutaneous disorder that primarily affects adults between 40 and 60 years of age Clinically, the disease presents with extremely fragile, flaccid bullae and painful, non-healing erosions that typically initiate in the oral mucosa before progressing to involve the skin and other mucous membranes

Pemphigus vulgaris is a rare, severe, chronic autoimmune mucocutaneous disorder that primarily affects adults between 40 and 60 years of age Pathophysiologically, it is characterized by pathogenic immunoglobulin G autoantibodies directed against desmoglein 3 and often desmoglein 1, which are critical cadherin proteins responsible for intercellular adhesion between keratinocytes Clinically, the disease presents with extremely fragile, flaccid bullae and painful, non-healing erosions that typicall...

This antibody-mediated disruption triggers intraepidermal acantholysis, resulting in widespread loss of cell-cell adhesion

Clinically, the disease presents with extremely fragile, flaccid bullae and painful, non-healing erosions that typically initiate in the oral mucosa before progressing to involve the skin and other mucous membranes

Clinically, the disease presents with extremely fragile, flaccid bullae and painful, non-healing erosions that typically initiate in the oral mucosa before progressing to involve the skin and other mucous membranes