Primary cutaneous anaplastic large cell lymphoma

Primary cutaneous anaplastic large cell lymphoma is an indolent subtype of cutaneous T-cell lymphoma within the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders It primarily affects the skin in adults, most commonly presenting in older individuals as solitary, clustered, or occasionally multifocal erythematous nodules, tumors, or ulcerated plaques Pathophysiologically, the condition is defined by diffuse dermal sheets of large atypical, pleomorphic, or anaplastic lymphoi...

Primary cutaneous anaplastic large cell lymphoma is an indolent subtype of cutaneous T-cell lymphoma within the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders Despite its high-grade histopathological appearance, it generally follows a favorable clinical course with absence of extracutaneous dissemination at initial diagnosis, aside from possible regional lymph node involvement

It primarily affects the skin in adults, most commonly presenting in older individuals as solitary, clustered, or occasionally multifocal erythematous nodules, tumors, or ulcerated plaques

It primarily affects the skin in adults, most commonly presenting in older individuals as solitary, clustered, or occasionally multifocal erythematous nodules, tumors, or ulcerated plaques

Pathophysiologically, the condition is defined by diffuse dermal sheets of large atypical, pleomorphic, or anaplastic lymphoid cells strongly expressing the CD30 surface antigen, typically lacking anaplastic lymphoma kinase expression

Despite its high-grade histopathological appearance, it generally follows a favorable clinical course with absence of extracutaneous dissemination at initial diagnosis, aside from possible regional lymph node involvement