Primary mediastinal large B-cell lymphoma

Primary mediastinal large B-cell lymphoma is an aggressive, distinct subtype of non-Hodgkin mature B-cell neoplasm that originates from thymic medullary B cells within the anterior mediastinum

Primary mediastinal large B-cell lymphoma is an aggressive, distinct subtype of non-Hodgkin mature B-cell neoplasm that originates from thymic medullary B cells within the anterior mediastinum Pathophysiologically, it shares molecular and genetic features with classic Hodgkin lymphoma, frequently exhibiting compartmentalizing fibrosis, constitutional NF-κB activation, and alterations in chromosome 9p24.1 that lead to PD-L1 overexpression

It most commonly affects adolescents and young adults, demonstrating a marked female predominance

It most commonly affects adolescents and young adults, demonstrating a marked female predominance Clinically, it typically presents as a rapidly expanding, bulky anterior mediastinal mass that directly invades adjacent thoracic structures, frequently causing cough, dyspnea, pleural or pericardial effusions, and superior vena cava syndrome

Pathophysiologically, it shares molecular and genetic features with classic Hodgkin lymphoma, frequently exhibiting compartmentalizing fibrosis, constitutional NF-κB activation, and alterations in chromosome 9p24.1 that lead to PD-L1 overexpression Clinically, it typically presents as a rapidly expanding, bulky anterior mediastinal mass that directly invades adjacent thoracic structures, frequently causing cough, dyspnea, pleural or pericardial effusions, and superior vena cava syndrome

Pathophysiologically, it shares molecular and genetic features with classic Hodgkin lymphoma, frequently exhibiting compartmentalizing fibrosis, constitutional NF-κB activation, and alterations in chromosome 9p24.1 that lead to PD-L1 overexpression

Clinically, it typically presents as a rapidly expanding, bulky anterior mediastinal mass that directly invades adjacent thoracic structures, frequently causing cough, dyspnea, pleural or pericardial effusions, and superior vena cava syndrome