Indication

Prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer

Prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer is an advanced, lethal malignancy of the male genitourinary system that has disseminated beyond the prostate to distant sites such as bones, lymph nodes, or visceral organs. Read more about Prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer

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About Prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer.

Prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer is an advanced, lethal malignancy of the male genitourinary system that has disseminated beyond the prostate to distant sites such as bones, lymph nodes, or visceral organs.

It is clinically defined by disease progression—evidenced by rising serum prostate-specific antigen levels or radiological tumor growth—despite achieving medical or surgical castrate levels of serum testosterone.

The condition is further characterized by the marked cell-surface overexpression of prostate-specific membrane antigen, a transmembrane glycoprotein typically identified via diagnostic positron emission tomography imaging.

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