Proteus mirabilis urinary tract infection

A *Proteus mirabilis* urinary tract infection is a bacterial infection of the urinary tract caused by the Gram-negative bacillus *Proteus mirabilis*, presenting clinically as lower tract cystitis or upper tract pyelonephritis While it can cause uncomplicated community-acquired infections, it predominantly affects vulnerable populations, including older adults, individuals with structural or functional urinary tract abnormalities, and patients undergoing long-term urinary catheterization A hallma...

A *Proteus mirabilis* urinary tract infection is a bacterial infection of the urinary tract caused by the Gram-negative bacillus *Proteus mirabilis*, presenting clinically as lower tract cystitis or upper tract pyelonephritis

While it can cause uncomplicated community-acquired infections, it predominantly affects vulnerable populations, including older adults, individuals with structural or functional urinary tract abnormalities, and patients undergoing long-term urinary catheterization

While it can cause uncomplicated community-acquired infections, it predominantly affects vulnerable populations, including older adults, individuals with structural or functional urinary tract abnormalities, and patients undergoing long-term urinary catheterization This alkalinizes the urine and precipitates magnesium ammonium phosphate and calcium phosphate, predisposing patients to catheter encrustation, biofilm formation, and the development of struvite urinary calculi (infection stones)

A hallmark pathophysiologic feature is the organism's robust production of urease, which hydrolyzes urea into ammonia and carbon dioxide This alkalinizes the urine and precipitates magnesium ammonium phosphate and calcium phosphate, predisposing patients to catheter encrustation, biofilm formation, and the development of struvite urinary calculi (infection stones)

This alkalinizes the urine and precipitates magnesium ammonium phosphate and calcium phosphate, predisposing patients to catheter encrustation, biofilm formation, and the development of struvite urinary calculi (infection stones)