Pulmonary hypertension associated with interstitial lung disease

Pulmonary hypertension associated with interstitial lung disease is a severe cardiovascular and pulmonary complication classified as World Health Organization Group 3 pulmonary hypertension

It occurs when sustained vascular remodeling and hypoxic vasoconstriction elevate pulmonary arterial pressures in adult populations affected by chronic fibrotic or inflammatory parenchymal lung disorders Clinically, affected patients present with disproportionate worsening of dyspnea, progressive exercise intolerance, elevated pulmonary vascular resistance, accelerated hypoxemia, and an elevated risk of subsequent right ventricular dysfunction

It occurs when sustained vascular remodeling and hypoxic vasoconstriction elevate pulmonary arterial pressures in adult populations affected by chronic fibrotic or inflammatory parenchymal lung disorders Pathophysiologically, the condition is characterized by precapillary pulmonary hypertension driven by parenchymal destruction, loss of functional capillary beds, and intrinsic vascular changes

Pathophysiologically, the condition is characterized by precapillary pulmonary hypertension driven by parenchymal destruction, loss of functional capillary beds, and intrinsic vascular changes Clinically, affected patients present with disproportionate worsening of dyspnea, progressive exercise intolerance, elevated pulmonary vascular resistance, accelerated hypoxemia, and an elevated risk of subsequent right ventricular dysfunction

Clinically, affected patients present with disproportionate worsening of dyspnea, progressive exercise intolerance, elevated pulmonary vascular resistance, accelerated hypoxemia, and an elevated risk of subsequent right ventricular dysfunction