Seizure due to isoniazid toxicity

Seizure due to isoniazid toxicity is a severe, life-threatening neurological complication resulting from acute supratherapeutic exposure or overdose of the antitubercular agent isoniazid

Seizure due to isoniazid toxicity is a severe, life-threatening neurological complication resulting from acute supratherapeutic exposure or overdose of the antitubercular agent isoniazid Pathophysiologically, isoniazid inhibits pyridoxine phosphokinase and binds pyridoxal 5'-phosphate, depleting active vitamin B6 and arresting glutamic acid decarboxylase activity This depletion profoundly diminishes gamma-aminobutyric acid synthesis, leading to widespread loss of central inhibitory neurotransmis...

It predominantly affects the central nervous system, occurring across all patient populations exposed to toxic levels

It predominantly affects the central nervous system, occurring across all patient populations exposed to toxic levels

Clinically, this manifests as intractable, recurrent generalized tonic-clonic convulsions or status epilepticus that typically resist standard anticonvulsant therapy and are frequently accompanied by profound high-anion-gap lactic acidosis and coma

Clinically, this manifests as intractable, recurrent generalized tonic-clonic convulsions or status epilepticus that typically resist standard anticonvulsant therapy and are frequently accompanied by profound high-anion-gap lactic acidosis and coma