Indication

Severe chronic pain

Severe chronic pain is an ongoing, debilitating sensory and emotional state persisting past standard tissue healing times, typically exceeding three months, and characterized by high-intensity discomfort that severely impairs daily functioning and quality of life. Read more about Severe chronic pain

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About Severe chronic pain.

Severe chronic pain is an ongoing, debilitating sensory and emotional state persisting past standard tissue healing times, typically exceeding three months, and characterized by high-intensity discomfort that severely impairs daily functioning and quality of life.

It affects diverse pediatric and adult populations and can involve multiple body regions via primary disorders, such as widespread nociplastic syndromes, or secondary etiologies including advanced malignancy, musculoskeletal degeneration, and severe neuropathies.

Pathophysiologically, it is driven by complex neurobiological dysregulation within the peripheral and central nervous systems, often involving peripheral sensitization, central hypersensitivity, impaired descending inhibitory pathways, and neuroinflammation.

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