Steatosis of liver

Steatosis of liver, also termed hepatic steatosis or fatty liver, is a clinicopathologic state characterized by the abnormal intracellular accumulation of lipids, primarily triglycerides, within the cytoplasm of hepatocytes

Steatosis of liver, also termed hepatic steatosis or fatty liver, is a clinicopathologic state characterized by the abnormal intracellular accumulation of lipids, primarily triglycerides, within the cytoplasm of hepatocytes Pathophysiologically, it stems from an imbalance between the hepatic uptake or de novo synthesis of fatty acids and their subsequent mitochondrial oxidation or export via very-low-density lipoproteins

It affects the hepatic system across diverse populations and is defined histologically when lipid droplets occupy at least 5% of hepatocytes, or radiologically by increased intrahepatic fat content While often asymptomatic and reversible in its early stages, hepatic steatosis serves as the foundational hallmark for both metabolic dysfunction-associated steatotic liver disease and alcohol-associated liver disease, carrying the potential to progress to steatohepatitis, fibrosis, and cirrhosis

It affects the hepatic system across diverse populations and is defined histologically when lipid droplets occupy at least 5% of hepatocytes, or radiologically by increased intrahepatic fat content

While often asymptomatic and reversible in its early stages, hepatic steatosis serves as the foundational hallmark for both metabolic dysfunction-associated steatotic liver disease and alcohol-associated liver disease, carrying the potential to progress to steatohepatitis, fibrosis, and cirrhosis