Indication

Tardive dyskinesia

Tardive dyskinesia is a persistent, potentially irreversible neurological movement disorder caused by prolonged exposure to dopamine receptor–blocking agents, primarily first- and second-generation antipsychotics or certain antiemetic medications. Read more about Tardive dyskinesia

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About Tardive dyskinesia.

Tardive dyskinesia is a persistent, potentially irreversible neurological movement disorder caused by prolonged exposure to dopamine receptor–blocking agents, primarily first- and second-generation antipsychotics or certain antiemetic medications.

It predominantly affects individuals receiving long-term treatment for psychiatric, mood, or gastrointestinal disorders, with higher vulnerability observed in older adults.

Clinically, it is characterized by involuntary, repetitive, purposeless hyperkinetic movements most commonly involving the orofacial musculature—such as tongue protrusion, lip smacking, and grimacing—as well as choreoathetoid movements of the limbs and trunk.

Pathophysiologically, the disorder is thought to result from neuroleptic-induced postsynaptic dopamine receptor supersensitivity and neuroplastic maladaptations within the basal ganglia motor circuitry.

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