Thrombotic microangiopathy following transplantation of hematopoietic stem cell

Thrombotic microangiopathy following transplantation of hematopoietic stem cell—commonly termed transplant-associated thrombotic microangiopathy (TA-TMA)—is a severe, multifactorial vascular complication occurring in pediatric and adult recipients of hematopoietic cell transplants Clinically, it presents as microangiopathic hemolytic anemia with schistocytes, progressive thrombocytopenia, and elevated lactate dehydrogenase, often accompanied by hypertension, proteinuria, and renal dysfunction or...

Thrombotic microangiopathy following transplantation of hematopoietic stem cell—commonly termed transplant-associated thrombotic microangiopathy (TA-TMA)—is a severe, multifactorial vascular complication occurring in pediatric and adult recipients of hematopoietic cell transplants The disorder primarily targets the microvasculature, where widespread endothelial cell injury and secondary complement dysregulation induce microvascular thrombosis, consumption of platelets, and mechanical erythrocyte...

The disorder primarily targets the microvasculature, where widespread endothelial cell injury and secondary complement dysregulation induce microvascular thrombosis, consumption of platelets, and mechanical erythrocyte destruction

The disorder primarily targets the microvasculature, where widespread endothelial cell injury and secondary complement dysregulation induce microvascular thrombosis, consumption of platelets, and mechanical erythrocyte destruction Clinically, it presents as microangiopathic hemolytic anemia with schistocytes, progressive thrombocytopenia, and elevated lactate dehydrogenase, often accompanied by hypertension, proteinuria, and renal dysfunction or multisystem organ failure

Clinically, it presents as microangiopathic hemolytic anemia with schistocytes, progressive thrombocytopenia, and elevated lactate dehydrogenase, often accompanied by hypertension, proteinuria, and renal dysfunction or multisystem organ failure