Transthyretin-related amyloid cardiomyopathy

Transthyretin-related amyloid cardiomyopathy (ATTR-CM) is a progressive, infiltrative myocardial disease caused by the extracellular accumulation of misfolded transthyretin protein fibrils within cardiac tissue The amyloid deposition leads to biventricular wall thickening, increased myocardial stiffness, and impaired ventricular filling, typically manifesting as restrictive cardiomyopathy, progressive heart failure, and cardiac conduction abnormalities

Transthyretin-related amyloid cardiomyopathy (ATTR-CM) is a progressive, infiltrative myocardial disease caused by the extracellular accumulation of misfolded transthyretin protein fibrils within cardiac tissue

This condition primarily affects the cardiovascular system in older adults, occurring either as an age-related wild-type disorder or as an inherited form resulting from pathogenic *TTR* gene variants

This condition primarily affects the cardiovascular system in older adults, occurring either as an age-related wild-type disorder or as an inherited form resulting from pathogenic *TTR* gene variants

The amyloid deposition leads to biventricular wall thickening, increased myocardial stiffness, and impaired ventricular filling, typically manifesting as restrictive cardiomyopathy, progressive heart failure, and cardiac conduction abnormalities