Indication

Typhoid vaccination

Typhoid vaccination is an active immunization procedure indicated for the prevention of typhoid fever, a systemic and potentially life-threatening enteric illness caused by the bacterium *Salmonella enterica* serotype Typhi. Read more about Typhoid vaccination

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About Typhoid vaccination.

Typhoid vaccination is an active immunization procedure indicated for the prevention of typhoid fever, a systemic and potentially life-threatening enteric illness caused by the bacterium *Salmonella enterica* serotype Typhi.

Acquired via the fecal-oral route through ingestion of contaminated food or water, the pathogen invades the intestinal mucosa, disseminates via the reticuloendothelial system into the bloodstream, and produces sustained bacteremia.

Clinically, infection is characterized by prolonged high fever, malaise, headache, abdominal pain, hepatosplenomegaly, and bowel disturbances, with severe complications including intestinal hemorrhage or perforation.

Immunization is primarily indicated for populations at elevated risk of exposure, including travelers visiting endemic regions with inadequate sanitation, household contacts or close associates of chronic carriers, and laboratory personnel who handle the organism.

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