XOLREMDI (mavorixafor)
CXCR4 CHEMOKINE RECEPTOR ANTAGONISTS·WARTS, HYPOGAMMAGLOBULINEMIA, INFECTIONS, MYELOKATHEXIS SYNDROME
X4 PHARMACEUTIC
Indication
Warts, hypogammaglobulinemia, infections, myelokathexis syndrome
Warts, hypogammaglobulinemia, infections, myelokathexis syndrome is a rare, inherited primary immunodeficiency and chronic neutropenic disorder predominantly caused by gain-of-function mutations in the *CXCR4* gene. Read more about Warts, hypogammaglobulinemia, infections, myelokathexis syndrome
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Coming soonWarts, hypogammaglobulinemia, infections, myelokathexis syndrome is a rare, inherited primary immunodeficiency and chronic neutropenic disorder predominantly caused by gain-of-function mutations in the *CXCR4* gene.
It affects both pediatric and adult populations, disrupting the hematologic and immune systems through excessive retention of mature neutrophils within the bone marrow, a defining phenomenon termed myelokathexis.
Clinically, affected individuals present with persistent peripheral severe neutropenia, lymphopenia, and reduced serum immunoglobulin concentrations, culminating in recurrent bacterial infections and an elevated susceptibility to extensive human papillomavirus-induced warts and associated mucosal malignancies.
- nih.gov
Warts, hypogammaglobulinemia, infections, myelokathexis syndrome is a rare, inherited primary immunodeficiency and chronic neutropenic disorder predominantly caused by gain-of-function mutations in the *CXCR4* gene
- nih.gov
Warts, hypogammaglobulinemia, infections, myelokathexis syndrome is a rare, inherited primary immunodeficiency and chronic neutropenic disorder predominantly caused by gain-of-function mutations in the *CXCR4* gene It affects both pediatric and adult populations, disrupting the hematologic and immune systems through excessive retention of mature neutrophils within the bone marrow, a defining phenomenon termed myelokathexis Clinically, affected individuals present with persistent peripheral sever...
- nih.gov
It affects both pediatric and adult populations, disrupting the hematologic and immune systems through excessive retention of mature neutrophils within the bone marrow, a defining phenomenon termed myelokathexis Clinically, affected individuals present with persistent peripheral severe neutropenia, lymphopenia, and reduced serum immunoglobulin concentrations, culminating in recurrent bacterial infections and an elevated susceptibility to extensive human papillomavirus-induced warts and associate...
- nih.gov
It affects both pediatric and adult populations, disrupting the hematologic and immune systems through excessive retention of mature neutrophils within the bone marrow, a defining phenomenon termed myelokathexis
- nih.gov
Clinically, affected individuals present with persistent peripheral severe neutropenia, lymphopenia, and reduced serum immunoglobulin concentrations, culminating in recurrent bacterial infections and an elevated susceptibility to extensive human papillomavirus-induced warts and associated mucosal malignancies
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