Clinical intelligence & editorial.

PubMed

Ustekinumab as a novel treatment of chronic nonbacterial osteomyelitis: a case report.

Background Chronic nonbacterial osteomyelitis (CNO) is a rare inflammatory disorder that commonly causes bone destruction in the metaphysis of long bones, pelvic and vertebral bones, the clavicle, and the mandible. CNO is often misdiagnosed and underreported. This presentation of debilitating back pain caused by CNO showcases diagnostic challenges and potential for novel therapeutic treatment. Case Description A 14-year-old male with Crohn’s disease presented with acute, worsening lower back...

Ustekinumab

Betcher A, Siegel R, Aggarwal K, Chen Y• January 16, 2026

PubMed

Knowledge and Confidence of Physician Assistant Students in Managing Patients with a Documented Penicillin Allergy.

Objective: Physician assistants (PAs) are frequently involved in managing acute bacterial infections in patients with documented penicillin (PCN) allergies. Inappropriate antibiotic choice in patients with existing allergies may place them at undue risk. This study aimed to assess the knowledge and confidence among PA students in managing patients with documented PCN allergies. Methods: An electronic survey was distributed to enrolled students in participating PA programs in North and South Caro...

Physician Assistant

Moody K, Weil D, O'Neal SJ, Sunshine N, Bookstaver PB• January 16, 2026

PubMed

A Multilayered Approach to Professionalism Assessment in Physician Assistant Education: Tracking Growth Beyond Zero-Tolerance Policies.

Abstract Introduction The impact of unprofessional behavior in medical training has been well-documented, with studies linking it to increased professional misconduct later in clinical practice, including breaches of ethical standards and license revocations. Notably, students with documented professionalism violations during physician assistant (PA) training face a 5-fold increase in the likelihood of postgraduate disciplinary actions. The condensed nature of PA education, averaging 27 months...

Physician Assistant

Diem E, Brandell S, Scanlon T, Wireman P• January 16, 2026

PubMed

Critical Reflections on Gentamicin Saline Irrigation for Appendectomy Wound Care.

I thoroughly read the paper by Bibek Shrestha et al. titled “Comparison of Gentamicin Saline Solution and Normal Saline in Reducing Surgical Site Infections in Open Appendectomy: A Randomized Controlled Trial” with keen interest. This research solves a clinically significant problem in surgical procedures, especially in resource‐constrained situations where open appendectomy is a frequent occurrence and affordable measures hold significance. Through a stringent comparison of the efficacy of gent...

Wound Care

Rana RUR, Fatima R, Arif S• January 16, 2026

PubMed

Sunlight-powered photodynamic therapy for painless diabetic wound care.

Chronic infected wounds are among the most debilitating complications of diabetes, often leading to prolonged hospitalization, antibiotic resistance, severe pain, and even limb amputation [1]. Photodynamic therapy (PDT) offers an attractive non-antibiotic strategy by generating reactive oxygen species (ROS) to eradicate pathogens, yet its clinical translation has been limited by shallow light penetration, treatment-associated pain, phototoxicity, and reliance on expensive laser equipment [2–4]....

Wound Care

Lu Y, Huang KB, Shabat D• January 16, 2026

PubMed

Novel trinucleotide mRNA capping reagents: improved synthetic route and efficient cotranscriptional incorporation in mRNA.

The 5′-N7-methylated guanosine triphosphate cap structure plays a critical role in mRNA translation and mRNA stability. The recent invention of cotranscriptional capping of mRNAs using trinucleotide capped primers (TCPs) allows for development of large-scale in vitro transcription (IVT) synthesis of mRNA carrying a eukaryotic Cap 1 structure (TCP-mRNA). Here we present a novel “one-pot-two-step” methodology for the synthesis of TCPs that improves the yield and simplifies the isolation and purifi...

Reagents

Xu C, Cousins R, Ilichev I, Ceja J, Ludford P, Begoyan V, Turner M, Santos M, Vo C, Rezvani F, Ujita A, Henderson J, Houston M, Zhao C, Lebedev AV• January 16, 2026

PubMed

Stable BF(2) Boracycles as Versatile Reagents for Selective Ortho C-H Functionalization.

Abstract The development of new boron reagents continues to play a crucial role in advancing modern organic synthesis, particularly in C–H functionalization and cross‐coupling reactions. Herein, we report a metal‐free, robust, and scalable multigram protocol for the synthesis of stable BF2 boracycles that require no column chromatography, providing a practical and efficient route to access this valuable boron species. The BF2 boracycles exhibit enhanced stability and reactivity, making them hig...

Reagents

Shinde GH, Babiker J, Mebrahtu M, Prigent A, Foucras G, Aher YN, Noa FMA, Johansson MJ, Košmrlj J, Jansen-van Vuuren RD, Cailly T, Sundén H• January 16, 2026

PubMed

Hydrogen Sulfide Inhibits H. pylori-Induced Gastric Fibroblast Activation: Implications for Cancer Prevention.

Highlights What are the main findings?Hp (cagA+vacA+)-induced inflammation reduces gastric fibroblast proliferation/viability and reprograms these cells toward a CAF-like phenotype (Twist upregulation/nuclear localization, increased FAP/FSP, enhanced IL-6/IL-8/HGF expression), upregulation of NF-κB/STAT3 activation and induction of the sulfur-metabolizing enzymes CBS, MPST and TST.The fast-releasing H2S donor NaHS (50–400 µM) attenuates Hp-induced fibroblast activation markers/secretome, reduce...

H. Pylori

Krzysiek-Maczka G, Targosz A, Bronowicka-Adamska P, Szczyrk U, Strzalka M, Mączka H, Wierdak M, Rodzon I, Czyz J, Brzozowski T, Ptak-Belowska A• January 16, 2026

PubMed

Characterization and Identification of the Ent-Kaurane Diterpenoids in Isodonis Excisoidis Herba Using UHPLC-LTQ-Orbitrap-MS.

Isodonis Excisoidis Herba (IEH) is a newly discovered herbal medicine used to treat esophageal cancer, chronic pharyngitis, and hepatitis, and ent-kaurane diterpenoids are its main active components. However, systematic studies on the chemical profile of ent-kaurane diterpenoids are lacking. In this study, UHPLC-LTQ-Orbitrap-MS was performed to investigate the fragmentation behaviors of three different types of ent-kaurane diterpenoids from IEH. Bridgehead-unsubstituted 7,20-epoxy-ent-kaurane di...

Ent

Sun X, Zhang L, Lian C, Chen S, Dai L, Han Y• January 16, 2026

PubMed

Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) for Obesity and Symptoms in Menopause: A Review.

Background: The effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in menopausal and postmenopausal women are not well characterized and may differ from other patient populations, given their different hormone profiles. Current research evaluating the effects of GLP-1RAs on weight loss, cardiovascular markers such as total cholesterol, and vasomotor symptoms (VMS) in this patient population is limited. Objective: This scoping review summarizes current articles on the effects of GLP...

Menopause

Graczyk NA, Bisschops J• January 16, 2026

PubMed

Racial disparities in the association between adverse childhood experiences and history of self-reported depression among cancer survivors.

Objective This study aimed to assess the association between the number of adverse childhood experiences (ACEs) and the history of depression among cancer survivors by race. Methods This study was a cross-sectional analysis of the 2020 Behavioral Risk Factor Surveillance System among 22,292 cancer survivors. The number of ACE experienced (zero, one, two-three, ≥ four) included questions assessing exposure to physical, emotional, and sexual household member substance misuse, incarceration, men...

Depression

Colucciello VJ, Babatunde OA, Gonzalez K, Adaralegbe N, Jefferson MS, Adams SA, Hughes Halbert C, Clark F, Nagar A, Osazuwa-Peters N, Adjei Boakye E• January 16, 2026

PubMed

Heterologous immunization modulates B-cell epitope competition between helper peptides and the MPER segment in MPER/liposome vaccines.

Subdominant B-cell immune responses to conserved epitopes are major obstacles in eliciting broadly neutralizing antibodies (bnAbs) against HIV-1 through natural infection or vaccination. Although the sequence conserved membrane proximal external region (MPER) of HIV-1 gp41 is partially occluded on the virion surface, epitope-focused immunogens could mitigate access limitations. Here, we found that a MPER/liposome vaccine delivered with a single CD4 T cell helper epitope results in a post-priming...

Vaccines And Immunization

Khan RA, Chen J, Donius L, Reinherz EL, Kim M• January 16, 2026