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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,609–1,620 of 2,098 articles

PubMed

The Relationship between Hemoglobin A1c and the Glucose Management Indicator and Glucose Metrics in Children and Adolescents with Type 1 Diabetes Mellitus Using Automated Insulin Delivery Systems.

Objective Hemoglobin A1c (HbA1c) remains the standard biomarker for long-term glycemic control in type 1 diabetes mellitus (T1D), butis incapable of capturing short-term glucose variability and acute excursions. This limitation is especially relevant in children with T1D who use continuous glucose monitoring systems (CGMS) and automated insulin delivery (AID) systems. The objective of this study was to evaluate the temporal relationship between HbA1c and the glucose management indicator (GMI),...

Articles
Arslan E, Balkı HG, Özalp Kızılay D, Demir G, Özen S, Darcan Ş, Gökşen D•
PubMed

Bone Health in Young Lung Transplant Recipients: A Retrospective Study.

Abstract Introduction There are limited data on the prevalence and treatment of low bone density in young lung transplant recipients (LTRs), even though osteoporosis is common in patients with end-stage lung disease and transplant recipients. This study aimed to assess bone health in young LTRs. Methods We retrospectively reviewed medical records for LTRs aged 18–50 at transplant. Outcomes included posttransplant low bone density (Z score < −2), osteoporotic fractures, and treatment data. R...

Articles
Lerman A, Shtraichman O, Rudman Y, Kramer MR, Dotan I, Tsvetov G, Diker Cohen T•
PubMed

Vitamins and minerals and their role in cancer: a comprehensive review.

Cancer remains a leading cause of morbidity and mortality worldwide, influenced by genetic, environmental, and lifestyle factors, including nutrition. This review explores the role of vitamins and minerals in cancer prevention and management, highlighting their critical functions in immune response, DNA synthesis, cellular repair, and antioxidant defense. Vitamins such as A, C, D, E, and the B-complex group, along with minerals like calcium, magnesium, and zinc, are essential for maintaining hea...

Articles
Garutti M, de Scordilli M, Alberti M, Mazzeo R, Michelotti A, Fagioli S, Del Conte A, Casirati A, Caccialanza R, Bartolini E, Puglisi F•
PubMed

Correction: Loss of the tumour suppressor LKB1/STK11 uncovers a leptin-mediated sensitivity mechanism to mitochondrial uncouplers for targeted cancer therapy.

Correction: Mol Cancer 23, 147 (2024) https://doi.org/10.1186/s12943-024-02061-4 Following publication of the original correspondence [1], the authors wish to extend their acknowledgements to provide a more clear and precise credit to Dr P Haramis, Dr L Mans and Dr G Gargiulo’s work that was included in their manuscript. First, they would like to thank Dr P Haramis and Dr L Mans for the work done in zebrafish and cite the data published in Dr Mans’ doctoral thesis [2] used in Figs. 1 C-F, S1B-...

Articles
Angelopoulou A, Theocharous G, Valakos D, Polyzou A, Magkouta S, Myrianthopoulos V, Havaki S, Fiorillo M, Tremi I, Vachlas K, Nisotakis T, Thanos DF, Pantazaki A, Kletsas D, Bartek J, Petty R, Thanos D, McCrimmon RJ, Papaspyropoulos A, Gorgoulis VG•
PubMed

Developing a Weight Management and Metabolic Health Program to support patient-centred, effective, and efficient treatment for veterans with overweight or obesity: protocol for a quality improvement programme.

Background: Veterans Affairs Medical Centers offer multiple weight-loss treatments, including a comprehensive lifestyle intervention program (i.e., MOVE!), anti-obesity medications (AOMs) and bariatric surgery. Yet, most eligible veterans do not receive these treatments. Aim: To describe the design, rationale, and planned evaluation of a comprehensive Weight Management and Metabolic Health program (WMMHP), consisting of (1) weight-focused visits with physicians or pharmacists trained in obesi...

Articles
Malhotra D, Henderson J, Turner CD, O'Rourke RW, McAuley KB, Heisler M, Otto M, Thomason C, O'Neill JL, Freeman K, Dunham MW, Bartley EP, Hess A, Kruse V, Ruttan K, Haeussler AL, Solomon G, Grondin C, Kim PS, Schildhouse RJ, Tremblay A, Griauzde DH•
PubMed

Reply to the Letter to the Editor: "Comment on 'Association Between Triglyceride-Glucose Index and Prognosis of Patients with Hypertrophic Cardiomyopathy and Heart Failure with Preserved Ejection Fraction'".

To the Editor, We sincerely thank the reader1 for their thoughtful and constructive comments regarding our study2 on the triglyceride-glucose (TyG) index in patients with hypertrophic cardiomyopathy (HCM) and heart failure with preserved ejection fraction (HFpEF). We appreciate the opportunity to further discuss the potential mechanisms and implications of our findings. The reader aptly characterizes the observed inverse relationship between the TyG index and mortality as a “metabolic paradox....

Articles
Zheng Y, Liu L, Li X, Liu T•
PubMed

Comment on "Association Between Triglyceride- Glucose Index and Prognosis of Patients with Hypertrophic Cardiomyopathy and Heart Failure with Preserved Ejection Fraction".

To the Editor, I read with great interest the article by Liu et al1 entitled “Association Between Triglyceride-Glucose Index and Prognosis of Patients with Hypertrophic Cardiomyopathy and Heart Failure with Preserved Ejection Fraction,” recently published in the Anatolian Journal of Cardiology [2025;29(11):619-629]. The authors deserve credit for addressing an underexplored intersection between metabolic dysregulation and myocardial structural disease. Their observation that a higher triglycer...

Articles
Yeter Arslan G•
PubMed

Reply to the Letter to the Editor: "Commentary on the Prognostic Interpretation of the Triglyceride-Glucose Index in Patients with Hypertrophic Cardiomyopathy and Heart Failure with Preserved Ejection Fraction".

To the Editor, We thank the reader1 for their thoughtful commentary and for engaging with our study2 on the triglyceride-glucose (TyG) index in patients with hypertrophic cardiomyopathy (HCM) and heart failure with preserved ejection fraction (HFpEF). We appreciate the opportunity to address the methodological and pathophysiological points raised. The reader rightly notes that an elevated TyG index is conventionally associated with insulin resistance and adverse outcomes in the general populat...

Articles
Zheng Y, Liu L, Li X, Liu T•
PubMed

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.

ABSTRACT T cell exhaustion represents a pivotal mechanism of immune escape in cancer, with its inherent heterogeneity and dynamic plasticity being key determinants of the variable responses and resistance to immune checkpoint inhibitors (ICIs). This review comprehensively delineates the multifaceted heterogeneity of exhausted T (TEX) cells, tracing their developmental trajectory from precursor exhausted T (TPEX) cells to terminally differentiated exhausted T (TEX‐term) cells. We highlight both...

Articles
Yu Y, Yao X, Wang Q, Yang M, Li R, Qin J, Zhuang J, Sun C•
PubMed

Resourcefulness training on cancer-related fatigue and fear of cancer recurrence in patients undergoing colorectal cancer chemotherapy: a quasi-experimental study.

Background Patients with colorectal cancer commonly experience problems, such as fear of cancer recurrence and cancer-related fatigue, which seriously affect their physical and mental health. This study aimed to investigate the applicability of resourcefulness training on patients with colorectal cancer undergoing chemotherapy and explore its impact on patients’ cancer-related fatigue scores, fear of cancer recurrence scores, and resourcefulness levels. Materials and methods Sixty chemotherap...

Articles
Gao L, Zheng Y, Han N, Wu X, Yuan H•
PubMed

Plant-derived food bioactives in bone health: from multi-targeted roles to molecular mechanisms in osteoporosis.

Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone mass and deterioration of bone microstructure. Current pharmacological treatments are often associated with significant side effects and poor patient compliance. In recent years, food bioactives—such as polyphenols, carotenoids, and saponins—have attracted growing interest for their multi-target and low-toxicity profiles in the prevention and management of OP. This review systematically elaborates the protective roles an...

Articles
Zhang Y, Xu L, Xu H, Zhang Y, Wang L, Jiang S, Sun Y, Yu Y•