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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 157–168 of 2,098 articles

PubMed

Screening in Human Genetics - new opportunities, new responsibilities.

Only a generation ago, genetic testing was almost exclusively performed for specific clinical indications: an affected individual, a suggestive family history, or prenatal findings requiring further clarification. In this setting, human genetics primarily served as a diagnostic discipline, helping to establish disease causes, define the chance of recurrence, and support clinical management. Today, genetic analyses are increasingly offered to individuals with the aim of identifying disease predis...

Articles
Schaaf CP, Rudnik-Schöneborn S•
PubMed

Causal relationship between educational attainment and complications of Type 2 diabetes: Mendelian randomization study.

Educational attainment (EA) is a critical metric for evaluating individual socioeconomic status, as it significantly impacts mortality rates and the occurrence of various diseases. This study aims to investigate the causal relationship between education and complications associated with type 2 diabetes mellitus, while also examining potential mediating pathways. To assess the causal relationship between EA and specific complications of type 2 diabetes, this study employs univariable Mendelian ra...

Articles
Han W, Wan Q•
PubMed

Magnetic resonance neurography-supported L3-L4 radiculitis presenting as refractory peripatellar neuropathic pain in a patient with diabetes: A case report.

Rationale: Peripatellar pain is usually attributed to local knee disorders. However, proximal neural lesions can also cause pain around the knee. Third and fourth lumbar (L3–L4) radiculitis presenting mainly as peripatellar neuropathic pain is uncommon and may be missed when typical radicular symptoms are absent. Patient concerns: A 75-year-old man with a more than 20-year history of type 2 diabetes presented with severe left peripatellar pain for 10 days. The pain was burning and stabbing an...

Articles
Huang X, Yang D, Wang J, Zheng B•
PubMed

Causal association between gestational diabetes mellitus and peripartum mental disorders: Evidence from two-sample Mendelian randomization.

Gestational diabetes mellitus (GDM) is associated with multiple maternal and neonatal complications, but its direct causal impact on peripartum mental health remains uncertain. This study used a two-sample Mendelian randomization (MR) approach to assess whether genetically predicted GDM increases the risk of peripartum mental disorders, including depression, anxiety, and suicidality. Genetic variants associated with GDM were obtained from the FinnGen consortium, and summary data for peripartum m...

Articles
Yang C, Song W, Lu K, Dang W, Zhang M, Cheng X, Liu L, Wu X•
PubMed

Can the Finnish Diabetes Risk Score (FINDRISC) identify gestational diabetes?: A multicenter cross-sectional study in Türkiye.

Gestational diabetes mellitus (GDM) is a common pregnancy complication with short- and long-term adverse outcomes for mother and child. The Finnish Diabetes Risk Score (FINDRISC) is a simple, validated questionnaire for type 2 diabetes risk, but its ability to identify GDM is not well established. In this multicenter cross-sectional study, 797 pregnant women at 24 to 28 weeks of gestation who attended 3 tertiary hospitals in Istanbul, Türkiye, between June and September 2024 completed the Turkis...

Articles
Dagci S, Sertbas Y, Kizilay V, Punduk Yilmaz M, Sertbas M, Ozsenel EB•
PubMed

Validation of a prognostic model for chronic obstructive pulmonary disease (COPD) and evaluation of methods to include related data.

Background and objectives Prognostic models estimate a patient’s individual risk of future health outcomes using clinical and demographic data, supporting treatment planning. Such models are particularly useful for chronic diseases, where predicting disease progression can help guide interventions and improve patient outcomes. In chronic obstructive pulmonary disease (COPD), several models have been developed to predict long-term mortality risk. However, these models are often trained on patien...

Articles
Elayan H, Broomfield J, Rutherford MJ, Sperrin M, Martin GP, Jenkins DA, Booth S•
PubMed

Fasting glucose-to-HDL cholesterol ratio and risk of MASLD in nonobese Chinese adults: A retrospective cohort study.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in nonobese individuals; however, reliable markers for early risk identification remain limited. The fasting glucose-to-high-density lipoprotein cholesterol (FHR) ratio, which reflects integrated glucolipid metabolism, has emerged as a potential indicator. This study aimed to evaluate the association between FHR and the incidence of MASLD in nonobese adults. This retrospective cohort study included 16,173...

Articles
Luo J, Zhuang Z, Xiong Y, Zhou H, Yi F, Gong D, Nie L, Wu X•
PubMed

Roles of TRIM proteins in cardiovascular diseases: From pathogenesis to therapeutic targeting (Review).

Cardiovascular diseases are driven by sustained mechanical stress, metabolic derangement, inflammation and oxidative injury, which progressively disrupt cellular homeostasis within the heart and vasculature. Although current therapeutic strategies have substantially improved clinical outcomes, most interventions primarily target downstream pathological manifestations rather than upstream regulatory mechanisms that determine stress adaptation and tissue remodeling. Tripartite motif (TRIM) protein...

Articles
Wang F, Xing Z, Gao Y, Gai Y•
PubMed

Incremental value of renal, metabolic, and inflammatory markers for prevalent self-reported cardiovascular disease across NHANES cycles: A repeated cross-sectional validation study.

Renal dysfunction, metabolic stress, and systemic inflammation are associated with cardiovascular disease (CVD), but their incremental value beyond routine clinical factors is uncertain. This repeated cross-sectional study used 7 National Health and Nutrition Examination Survey (NHANES) cycles (2005–2018) for development and leave-one-cycle-out validation. The primary outcome was prevalent self-reported CVD. A locked clinical core was extended with estimated glomerular filtration rate plus log2...

Articles
Li H, Li X, Shi X•
PubMed

Nucleotide metabolism and cervical cancer: A comprehensive study of molecular subtypes and therapeutic targets.

Cervical cancer (CC) is among the most prevalent malignancies in women worldwide. Tumor progression involves profound metabolic reprogramming, in which nucleotide metabolism sustains deoxyribonucleic acid/ribonucleic acid synthesis and proliferation; however, its role in CC remains unclear. Transcriptomic and clinical data of CC patients were obtained from The Cancer Genome Atlas. Nonnegative matrix factorization classified patients into molecular subtypes based on nucleotide metabolism-related...

Articles
Li F, Bao C, Liu Y, Liu B, Zhai F•
PubMed

Prognostic impact of positive peritoneal washing cytology in surgically treated cervical cancer.

Positive peritoneal washing cytology is an uncommon but potentially clinically relevant finding in cervical cancer. This retrospective cohort study evaluated its association with recurrence, survival, and metastasis-related biomarkers in patients undergoing open surgery for cervical cancer between 2018 and 2023. A total of 120 patients were classified as peritoneal washing cytology-positive (n = 32) or cytology-negative (n = 88). Baseline clinicopathological characteristics were broadly comparab...

Articles
Zhang Q, Li X, Wang Q, Lin Z, Wang T•
PubMed

Development, validation, and testing of an agriculture support exoskeleton in adjunct to conventional physiotherapy for farm labourers with chronic low back pain: A two-phase, mixed-methods, quasi-experimental pilot study protocol.

Background Low back pain (LBP) affects 619 million people globally, with projections reaching 843 million by 2050. Farm labourers exhibit markedly higher prevalence than the general population, with lifetime (70–85%), 12-month (15–45%), and point (approximately 30%) prevalences driven by sustained trunk flexion, repetitive manual handling, and limited access to ergonomic or rehabilitative interventions. While conventional physiotherapy is the cornerstone of chronic LBP (CLBP) management, its ef...

Articles
Kaur G, Qureshi I, Bagde A, Sarode B, Jolhe DA, Nistane VM•