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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,669–1,680 of 2,098 articles

PubMed

Performance, blood parameters, ruminal fermentation and microbial community of dairy cows supplemented with Saccharomyces cerevisiae fermentation product from dry-off to early lactation.

Abstract Dairy cows experience oxidative stress, inflammation, and immune dysfunction during the transition from dry-off to early lactation. Postbiotics such as Saccharomyces cerevisiae fermentation product (SCFP), consisting of nonliving microorganisms with or without their components, have beneficial effects on the production efficiency and immune function of dairy cows. The objective of this study was to evaluate the effects of SCFP on milk production, milk composition, ruminal fermentation,...

Articles
Xu Y, Xiao J, Zhuang Y, Gao D, Jiang W, Hou G, Zhao X, Li S, Chen T, Li S, Zhang S, Huang Y, Liu S, Yoon I, Shi W, Li M, Wang W, Li S, Cao Z•
PubMed

Changes in body composition and plasma metabolites throughout lactation in high- and low-producing Saanen dairy goats.

Abstract This experiment investigated changes in body composition throughout lactation in dairy goats using non-invasive methods of body composition estimation including dual-energy X-ray absorptiometry (DEXA), body weight (BW), body condition score (BCS), and body mass index (BMI) in lactating Saanen dairy goats (20 high producers and 20 low producers). Body composition was measured on four occasions, early lactation (EL, 23 ± 6 DIM), mid lactation (ML, 107 ± 6 DIM), late lactation (LL, 206 ±...

Articles
Kirkham JL, Zamuner F, Cameron AWN, Carpenter EK, Leury BJ, DiGiacomo K•
PubMed

Phenotypic and genetic analysis of somatic cell score response to heat stress in first lactation Holstein cattle.

Abstract Previous studies have examined the effects of heat stress on dairy cattle and have estimated genetic parameters of heat tolerance for milk production traits. To further investigate heat stress in Canadian dairy cattle and to identify potential mitigation strategies through genetic selection, this study evaluated the relationship between somatic cell score (SCS) and the temperature-humidity index (THI) in different regions across Canada. The association between THI and SCS was assessed...

Articles
Campos IL, Jahnel RE, Oliveira HR, Miglior F, Baes CF, Schenkel FS•
PubMed

A Comparison of Vessel Density in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma Patients Using OCT Angiography.

Purpose To compare global peripapillary and perifoveal vessel densities between primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients with the same glaucoma severity using optical coherence tomography angiography (OCTA). Methods Subjects with POAG or NTG were recruited consecutively at the glaucoma clinic of the University of California at San Francisco. The glaucoma severity was graded as early, moderate, or severe based on the Hodapp-Parrish-Anderson Visual Field Cri...

Articles
Zehavi-Dorin T, Kutzscher AE, Badr M, Mora M, Shyu Y, Porco TC, Stamper RL•
PubMed

Association between Allergen Sensitization and Open-Angle Glaucoma: An Analysis Using 2010 Korea National Health and Nutrition Examination Survey (KNHANES) Data.

Purpose We sought to investigate the association between allergen-specific immunoglobulin E (IgE) sensitization and open-angle glaucoma (OAG) using a nationally representative South Korean population. Methods This cross-sectional study used data from the 2010 Korea National Health and Nutrition Examination Survey (KNHANES). Among 8,958 participants, 1,334 subjects with complete ophthalmologic and allergen-specific IgE test results were included. Sensitization to indoor allergens (house dust m...

Articles
Song JE, Kim YT, Kim JM•
PubMed

Fungal-specific IgG responses in allergic conjunctivitis: comparison with IgE and immunological implications.

Background Immunoglobulin G (IgG) is the most abundant antibody class in the bloodstream and is characterized by a long half-life compared to other immunoglobulins. While IgG plays a key role in host defense against infections, it is also known to be elevated in chronic inflammatory conditions. This study aimed to evaluate serum levels of fungus-specific Immunoglobulin E (IgE) and IgG antibodies in patients with allergic conjunctivitis and to investigate their associations with disease severity...

Articles
Mimura T•
PubMed

Hashimoto's Thyroiditis with Subclinical Hypothyroidism and Multi-System Symptoms: A Case of a Middle-Aged Male.

Abstract Hashimoto’s thyroiditis (HT) is a chronic autoimmune disease with lymphocytic infiltration of the thyroid gland and autoantibodies against endogenous components. A 45-year-old male professor at an academic institution with positive family history for autoimmune diseases among his brother and sister came to clinical hospital because of unspecific systemic symptoms, elevated TSH, low normal Free T4 (fT4), positivity autoantibodies against the thyroid gland. The biochemical signs of infla...

Articles
Ahmed WAM•
PubMed

Clinical Trial Endpoints for Perianal Fistulizing Crohn's Disease.

Perianal fistulizing Crohn's disease (pCD), a structurally damaging condition of the anorectum and perineum, can result in debilitating symptoms and significantly impair quality of life. The lack of high-quality randomized controlled trials (RCTs) with primary endpoints specifically validated for pCD has contributed to suboptimal treatment recommendations. This review discusses considerations for pCD RCTs and provides expert opinion on current endpoints in the context of guidance from regulatory...

Articles
Reinisch W, Atreya R, Rieder F, Jairath V, Rimola J, Peyrin-Biroulet L, Tozer P, Buskens CJ, Hart A•
PubMed

Effects of upadacitinib or adalimumab on pain in rheumatoid arthritis and psoriatic arthritis: results from randomised phase 3 studies.

Abstract Introduction Patients with rheumatoid (RA) or psoriatic (PsA) arthritis can experience debilitating pain. Methods Post hoc analyses of phase 3, double-blind studies in patients with active disease despite treatment (SELECT-COMPARE, SELECT-PsA 1) assessed the effects of upadacitinib or adalimumab versus placebo on pain in patients with attenuation of inflammation (AoI) versus remaining inflammation at weeks 12 and 24/26 (PsA/RA). Further, a mediation analysis assessed the direct/indi...

Articles
Taylor PC, Kavanaugh A, Bessette L, Fautrel B, Takeuchi T, Garrison A, Gao T, Lippe R, Caballero D, Phillips C, Mease PJ•
PubMed

Postoperative Pyoderma Gangrenosum: Rare Infection Mimic and Diagnostic Challenge - A Case Report.

Abstract Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that can occur in the postoperative period, often mimicking surgical site infections (SSIs). The clinical overlap between PG and SSIs – including erythema, wound dehiscence, and purulent discharge – makes timely diagnosis challenging. Case Presentation A 61-year-old female with a history of ovarian cancer and metachronous liver metastasis underwent an open left hemihepatectomy. On the fifth postoperative day, she...

Articles
Aldarwish S, Schafmayer C, Hinz S•
PubMed

Secukinumab-Induced Delayed Behçet-Like Reaction in a Patient with Plaque Psoriasis: A Case Report.

Purpose This report presents a rare paradoxical reaction manifesting as Behçet’s-like features, which developed three months following the initiation of secukinumab therapy for psoriasis. Patients and Methods A 38-year-old female with a 30-year history of plaque psoriasis achieved significant remission of psoriatic lesions following seven doses of secukinumab (cumulative dose: 2100 mg). However, she subsequently developed systemic adverse events, including pharyngodynia, painful tonsillar and...

Articles
Wei Y, Zhang P, Chuan J, Ye J, Liu T•
PubMed

A randomized, double-blinded trial to evaluate two therapeutic foods as adjunctive therapies in dogs with environmental and/or food-induced atopic dermatitis.

Abstract This study evaluated changes in pruritus, skin lesions, and gastrointestinal signs (G) in dogs fed a positive Control food, Hill’s Prescription Diet d/d Potato & Venison (Hill’s Pet Nutrition, Topeka, KS, USA) compared to a Test food, Hill’s Prescription Diet Derm Complete (Hill’s Pet Nutrition, Topeka, KS, USA), over an 8-wk period. We hypothesized that feeding either food would result in improvements in skin lesions and pruritus when compared to baseline while maintaining positive GI...

Articles
Yanes C, LeRoy M, Senter D, Motsinger LA, Key MA•