Sign in Register

Clinical intelligence & editorial.

Advertisement

Advertisement

Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,705–1,716 of 2,098 articles

PubMed

IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis.

Background Psoriasis and atopic dermatitis (AD) are two prevalent inflammatory skin disorders, each characterized by distinct adaptive immune responses. However, recent evidence suggests that these diseases may share overlapping immune mechanisms, especially concerning keratinocyte function. The specific cytokines that coordinate these inflammatory pathways remain largely undefined. Methods The expression of IL-27 and its receptor was analyzed using data derived from GEO datasets. Imiquimod-i...

Articles
Chen Z, Cui L, Lan Z, Lin S, Yang N, Li S, Zhao Z, Cai J, Wang Y, Liu T, Yu Y, Lu J, Zhang X, Guo C, Gu J, Yu Q, Shi Y•
PubMed

Real-World Benefit of Tildrakizumab for Moderate-to-Severe Plaque Psoriasis: Findings from a Systematic Literature Review and Meta-Analysis.

Introduction Plaque psoriasis (PsO) is an inflammatory skin disease that can impair quality of life. Tildrakizumab, an anti-IL-23 p19 monoclonal antibody, offers a treatment option for patients eligible for systemic therapy or phototherapy, but real-world results have not been comprehensively analyzed. This systematic review and meta-analysis evaluated real-world effectiveness, quality-of-life impact, and safety of tildrakizumab for treatment of moderate-to-severe plaque PsO, alone and relative...

Articles
Gottlieb S, Farberg AS, Bhatia N, Fazeli MS, Hofer K, Lam O, Barghout V, Mathew J, Ferro TJ•
PubMed

Case Report: Guillain-Barré syndrome temporally associated with levofloxacin exposure and improvement following efgartigimod treatment.

Levofloxacin, the L-isomer of the racemic fluoroquinolone ofloxacin, is a broad-spectrum antibiotic with broad clinical applications in both prophylactic and therapeutic indications. However, it has been associated with various adverse reactions, including Guillain−Barré syndrome (GBS). GBS is an immune-mediated peripheral neuropathy that typically presents with acute-onset symmetrical flaccid paralysis. Here, we report a case of GBS temporally associated with levofloxacin exposure that improved...

Articles
Xie S, Zhang Y, Shen F, Wu L, Tang Y, Li J•
PubMed

Repurposing insights: experimental and pharmacological approach on L-captopril and dimercaprol as metallo-β-lactamase inhibitors.

Abstract The design of specific inhibitors of metallo-β-lactamases (MBL) is one of the priority research lines due to the spread of carbapenem resistant bacterial strains which limits therapeutic options. In parallel, the investigation of new uses of known medicines is prompted by regulatory agencies. In this work, the potential MBL inhibitory potency of L-captopril (an antihypertensive drug) and dimercaprol (used in poisoning by metals) was investigated in a clinical collection of Enterobacter...

Articles
Rodríguez-Avial I, Torres S, Puglla Y, Pérez-Martín L, Sebastianes JL, Delgado-Iribarren A, Culebras E, Valderrama MJ•
PubMed

High-performing Nurse Managers Reduce Falls Through Registered Nurse Collaboration.

Objective: This study examines collaborative relationships among nurses as the pathway through which nurse manager (NM) leadership influences fall rates. Background: Research demonstrates that NMs play a critical role in fostering healthy work environments through leadership that fosters mutual trust and respect. By cultivating strong collaborative relationships among nurses within their units, NMs promote a cohesive team dynamic that directly improves patient safety. Methods: Data from the...

Articles
Welch TD, Pascale A, Smith TB, Warshawsky NE•
PubMed

Understanding capability, opportunity, and motivation for at-home COVID-19 testing in underserved populations during the pandemic.

Abstract Background and purpose We investigated the capabilities, opportunities and motivations associated with decision making related to at-home COVID-19 testing in populations most affected by the pandemic. Methods We conducted semi-structured interviews to explore the capability, opportunity and motivation for COVID-19 testing by the pandemic populations most affected by the pandemic. Interviews were carried out according to the Critical Incident Technique, and analysis and interpretatio...

Articles
Pierce JH, Taber P, Stevens L, Rush A, Benson R, Staes C, King AJ, Schlechter CR, Kaphingst KA, Wetter DW, Del Fiol G•
PubMed

Genetic profiling via a novel PCR-RFLP method enabled identification of four genera of anaerobic gut fungi isolated from nyala, giraffe, and zebra hosts.

Abstract Herbivore gut microbiomes may contain a diversity of anaerobic gut fungi (AGF, phylum Neocallimastigomycota), important for fibre degradation. To perform functional studies and elucidate niches of AGF species, fungal isolates must be obtained into axenic culture, which is a resource-intensive process. Here, we leverage the integration of morphological and functional assessments of AGF isolates with a newly developed Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PC...

Articles
Edge L, Duan P, Kerangart S, Buckner AM, van Munster JM•
PubMed

A scoping review of e/mHealth interventions for weight management in racial and ethnic minority adults in the United States.

Abstract Importance Obesity and chronic diseases disproportionately burden racial/ethnic minority adults in the United States (U.S.) (eg, Black, Hispanic/Latino, Asian, American Indian/Alaska Native, and Native Hawaiian/Pacific Islander), partially owing to barriers to receiving obesity treatment. While eHealth/mHealth-supported interventions offer a potential scalable solution and have proliferated in recent years, the last evidence synthesis was published in 2018. Objective Given the wide...

Articles
Ajilogba CF, Briggs RP, Battalio SL, Nguyen C, Wafford E, Marchese SH, Spring B, Pfammatter AF•
PubMed

Pupillary Pain Index-Guided Postoperative Pain Therapy in ENT Surgery: A Randomized Trial.

Background: Postoperative pain levels and opioid requirements vary considerably, even among patients undergoing similar surgical interventions. The pupillary pain index—a pupillometry-derived measure of nociception-antinociception balance—may help individualize postoperative analgesia. We therefore tested the hypothesis that a pupillary pain index-guided opioid titration at the end of surgery reduces postoperative pain and opioid consumption compared with standard care. Methods: At the end of su...

Articles
Windpassinger M, Prusak M, Yeghiazaryan L, Ristl R, Ott S, Müller-Wirtz LM, Ruetzler K•
PubMed

The Effects of Probiotic Yogurt and Resistance Training on Body Composition and Metabolic Parameters in Post-bariatric Surgery Patients: A Randomized Controlled Trial.

Background Bariatric surgery (BS) is an effective intervention for morbid obesity; however, it is often accompanied by undesirable muscle mass loss, which can negatively affect metabolic function and physical performance. Probiotics and resistance training (RT) have been studied discretely to address this complication. The present randomized controlled trial investigated the independent and combined effects of fortified yogurt (FY) and RT on muscle preservation and related health outcomes in po...

Articles
Rajabi S, Askarpour M, Haghighat N, Eskandari MH, Hosseini B, Hosseini SV, Bagheri R, Famouri M, Babajafari S•
PubMed

The effect of dexmedetomidine on rocuronium-induced neuromuscular blockade and its reversal by sugammadex.

Background Dexmedetomidine (DEX) is increasingly used in the intensive care unit for sedation and also serves as an adjuvant in general anesthesia and in procedural sedations. We tested whether dexmedetomidine at different concentrations influences the activity of the neuromuscular junction at the diaphragm and whether DEX has an impact on the action of rocuronium at the diaphragm as well as the reversal of the neuromuscular block by sugammadex. Methods 20 male Wistar rat phrenic nerve–hemidi...

Articles
Fedor M, Sallai N, Fülesdi B, Fábián ÁI•
PubMed

Frailty and its association with mental health and quality of life in multiple sclerosis: A cross-sectional study.

Background: With the increasing median age of people with multiple sclerosis (MS), age-related syndromes such as frailty have emerged as new challenges to patient well-being. Prior research on frailty in MS has primarily focused on physical aspects, leaving the relationship between frailty and mental health unexplored. Objective: To investigate the associations between frailty, mental health, and quality of life (QoL) in people with MS. Design: Cross-sectional questionnaire-based study cond...

Articles
Al Worikat N, Zanotto A, Lynch SG, Thuringer AJ, Sosnoff JJ, Zanotto T•