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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,729–1,740 of 2,098 articles

PubMed

The effect of a positive psychology skill enhancement program on the sense of well-being in patients with chronic heart failure.

Background Chronic heart failure (CHF) can lead to significant psychological changes, including a decrease in the sense of well-being in patients. This study aimed to determine the effect of a positive psychology skill enhancement program on the sense of well-being in patients with CHF. Methods In this randomized controlled trial, 78 hospitalized patients with CHF at Chamran Medical Center in Isfahan were randomly assigned to an intervention group (n = 39) and a control group (n = 39). The po...

Articles
Zeinali N, Akbari M, Ghezelbash S•
PubMed

Efficacy of sacubitril/valsartan sodium combined with simvastatin in treating chronic heart failure with arrhythmia and its effects on IL-6, IL-8, and TNF-α.

Background To explore, in conjunction with clinical practice, the efficacy of different pharmacological treatment regimens for patients with chronic heart failure complicated by arrhythmia, and their effects on inflammatory factor levels. Methods A total of 96 patients with chronic heart failure and arrhythmia treated at our hospital from June 2022 to January 2025 were selected and randomly assigned by envelope method into a combination therapy group and a simvastatin group. The simvastatin g...

Articles
Li J, Wang Z•
PubMed

TLR7 F507S gain-of-function mutation presenting with early-onset SLE and hypertriglyceridemia: Response to JAK inhibition.

We present a patient harboring the TLR7 F507S mutation who initially presented with refractory thrombocytopenia that evolved into SLE with subtle neurologic features, accompanied by hypertriglyceridemia. Both hematological and metabolic features responded to ruxolitinib, thereby expanding the phenotypic spectrum and therapeutic understanding of TLR7 GOF disease.

Articles
Parvaneh N, Karami H, Shahbaznejad L, Rezaei Z, Rostami P, Shahrooei M, Ziaee V•
PubMed

Biochemical characterisation of familial hypercholesterolemia: Associations between genetic and lipid profiles.

Background Familial hypercholesterolemia (FH) is characterised by elevated low-density lipoprotein cholesterol (LDL-C) levels and an increased risk of premature cardiovascular disease. The present study aimed to investigate the genetic background, associated biochemical profiles, clinical manifestations, and therapeutic response in patients with clinically suspected FH in Serbia. Methods A total of 101 patients with clinically suspected FH were recruited from the Clinic for Endocrinology, Dia...

Articles
Singh LS, Gašić V, Komazec J, Grubiša I, Popović L, Rasulić I, Petakov A, Mitrović M, Mihailović E, Pavlović S, Lalić K•
PubMed

Ameliorative effects of tallow and olive oil on hyperlipidemia-induced atherogenesis in male albino rats.

Hyperlipidemia and atherosclerosis are the major contributors to cardiovascular morbidity and mortality worldwide. This study aimed to evaluate the ameliorative effects of sheep tallow (SHT), bovine tallow (BT), and olive oil (OL) on lipid profiles, oxidative stress, inflammation, and atherosclerotic lesions in a rat model of atherogenesis induced by a high-fat diet. Rat groups received an atherogenic diet (AGD) containing cholesterol, cholic acid, and thiouracil for 12 weeks to induce atheroscl...

Articles
Al-Subari AA, Al-Khatib BY, Al-Tamimi AHS, Al-Arami AM, Naji KM•
PubMed

A Unique and Extensive Constellation of Late Radiation Effects in a Single Patient Following High-Dose Radiation Therapy for Childhood Hodgkin's Lymphoma.

Childhood cancer survivors treated with large-field radiation may develop late secondary effects across multiple organ systems. We present a 60-year-old male whose PET/CT revealed an absent thyroid gland with multiple metastatic foci, a surgically absent spleen and bladder with an ileal conduit, severe pulmonary outflow tract calcifications, and transcatheter aortic valve replacement (TAVR), bilateral proximal humeral osteonecrosis, and bilateral total hip arthroplasties. Though each individual...

Articles
Fryer JM, Fuller EB, Dinh TB, Padro DT•
PubMed

Risk of opioid overdose during buprenorphine treatment for opioid use disorder in the fentanyl era.

Background: For patients who use fentanyl, higher than currently recommended maintenance doses of buprenorphine treatment for opioid use disorder (OUD) may be needed to prevent cravings and withdrawal, but some clinicians and regulators are concerned that higher doses may increase overdose risk. We evaluated buprenorphine effectiveness for overdose prevention in the fentanyl era. Methods: We conducted a retrospective cohort study of Rhode Island residents initiating buprenorphine for OUD (Oct...

Articles
Chambers LC, Hallowell BD, Zullo AR, Rodriguez M, Khan MA, Berk J, Gaither R, Daly M, Wightman RS, Beaudoin FL•
PubMed

Adjuvants enhance protective antibodies against seasonal influenza viruses following a single vaccination of Fluzone.

Fluzone is a commercial, split-inactivated influenza virus vaccine produced from embryonated chicken eggs and administered via intramuscular injection. One strategy to increase the potency of this vaccine is to formulate with an effective adjuvant. To address this goal, mice were vaccinated with Fluzone mixed with either squalane oil-in-water adjuvant (Addavax) or a combination of a synthetic toll-like receptor (TLR) 4 and TLR7/8 agonist (TRAC478). Mice vaccinated with vaccine plus adjuvant had...

Articles
Thomas MH, Carlock MA, Ross TM•
PubMed

Once-weekly insulin icodec versus once-daily insulin degludec for type 2 diabetes in China: A cost-utility and budget impact analysis.

Abstract Aims Insulin icodec, the first once‐weekly basal insulin analogue, was approved in China in 2024. Although it has demonstrated robust clinical efficacy, its budget impact remains unknown, and the long‐term cost‐utility within the reimbursement context needs further estimates. This study evaluated the long‐term cost‐utility of once‐weekly insulin icodec compared with once‐daily insulin degludec in China. Materials and methods We used the validated IHE Diabetes Cohort Model to simulat...

Articles
Tong X, Zhang Y, Zhang L, Zhang L•
PubMed

Advancing pharmacist involvement in surgical prehabilitation: a call to action for global pharmacy practice.

Prehabilitation has emerged as a proactive, multimodal strategy in perioperative care, aiming to enhance functional capacity and resilience before surgery through medical optimization, exercise, nutrition, and psychological support. Despite their multidisciplinary nature, pharmacists are underutilized in this evolving field. Pharmacists are uniquely positioned to advance prehabilitation by applying Medication Therapy Management (MTM) and Collaborative Drug Therapy Management (CDTM) models to ide...

Articles
Wang Y, Lu J, Wu J, Wang R, Wei L, Li Y, Zeng Y, Li X, Chen J, Ji B, Liu T, Wu H, Wang J, Mai H, Zheng P, Yu S, Chen P, Yang C, Yu P, Mo X, Chen Y, Zheng Z•
PubMed

HIV Care for Adolescents and Young Adults: Comparing Nurse Practitioner and Physician Care in Engagement, Trust, and Clinical Outcomes.

Background Shortages in the HIV workforce threaten equitable access to care for youth with HIV (YWH) experiencing high rates of undiagnosed infection and suboptimal engagement. Nurse practitioners (NPs) may expand HIV care capacity, but evidence is limited. Methods We conducted a cross-sectional study in two U.S. adolescent and adult HIV programs. Electronic health record data were merged with patient-reported surveys assessing trust, adherence, and stigma across an eight-month pre– and post–...

Articles
Barr EA, Courtwright SE, Malone-Thomas S, Silveira L, Kacanek D, Cook P, Reed SM, Dunlevy H•
PubMed

ECG and imaging manifestations of cardiomyopathy in adults with Duchenne muscular dystrophy.

Background / Aims Cardiomyopathy is universally penetrant in young adults with Duchenne muscular dystrophy (DMD), and is increasingly the preponderant cause of death. We describe the ECG, echocardiography and cardiac MRI (CMR) findings associated with this disease, and the level of agreement between imaging modalities, highlighting the obstacles encountered in high rates of failed diagnostic cardiac imaging in our DMD multidisciplinary care centre. Methods and results We followed all patients...

Articles
Murray PC, Pollock A, Hewitt K, O'Sullivan J, Sheahan A, Sheahan R•