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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 2,017–2,028 of 2,098 articles

PubMed

Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology.

ABSTRACT Background Melasma is a chronic, relapsing hyperpigmentation disorder driven by complex interactions among genetic predisposition, hormonal fluctuations, UV exposure, oxidative stress, inflammation, and photoaging. Its psychosocial impact is substantial, especially among women with darker skin types, and treatment remains challenging due to its multifactorial pathogenesis and high recurrence rates. Aims This review aims to synthesize current knowledge on melasma pathophysiology, hig...

Articles
Liao T, Luo R, Deng Y, Yang H, Du Y•
PubMed

Next-Generation Immune Checkpoints and Tumor Microenvironment Modulation in Cancer Immunotherapy.

Immunotherapy has reshaped the oncology landscape by enabling the immune system to recognize and eliminate malignant cells. Although immune checkpoint inhibitors (ICIs) targeting cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4), programmed cell death‐1 (PD‐1), and programmed death‐ligand 1 (PD‐L1) have achieved durable responses in several cancers, their therapeutic benefit remains limited to a subset of patients, largely due to immune evasion, tumor heterogeneity, and immunosuppressive feat...

Articles
Bautista J, Echeverría CE, Maldonado-Noboa I, Adatty-Molina J, Suárez Urresta S, Coral-Riofrio EC, Araujo-Abad S, Kyriakidis NC, López-Cortés A•
PubMed

Comparative analysis of second and third-generation nanobody-based CAR-NK cells targeting PSMA in prostate cancer immunotherapy: In silico and in vitro studies.

Objective(s): The use of CAR technology in the treatment of cancer cells is progressing, as well as the use of CAR T-cell in the treatment of blood malignancies is in the clinical trial stage. In this study, have compared the second and third generation CAR expressed in NK cells in dealing with prostate cancer cells. Materials and Methods: To optimize the CAR design for detection of NK-92 cells, an in silico approach to select between two tags (Flag and c-Myc tags) was initially employed, ult...

Articles
Gandomkar Ghalhar M, Karami Vandishi A, Ramazani A, Hajari Taheri F, Sharifzadeh Z, Abolhassani M, Soleimani M, Taghipour N, van Weerden WM, Bandehpour M, Hassani M, Bagherzadeh K•
PubMed

Resveratrol as an immune checkpoint inhibitor to enhance the efficacy of breast cancer immunotherapy.

A major goal in cancer treatment is to convert “cold” tumors into “hot” ones by altering the tumor microenvironment (TME). Breast cancer is often a cold tumor and is resistant to immunotherapy. Resveratrol is a polyphenolic compound found in grapes, with antioxidant, anti-inflammatory, and potential cardioprotective and anti-aging properties. Resveratrol promotes the conversion of immunologically cold breast tumors into hot tumors, thereby increasing the efficacy of immunotherapy. This article r...

Articles
Alamolhodaei NS, Hudson BI, Mosaffa F, Boozari M•
PubMed

Double Q-Learning for Intelligent Multi-Drug Scheduling in Cancer Chemotherapy Optimisation.

ABSTRACT Chemotherapy scheduling poses a challenging control problem due to the need to suppress tumour growth whilst maintaining systemic toxicity within clinically acceptable limits. This study develops a double Q‐learning–based controller for optimising daily dosing of a three‐drug regimen consisting of cisplatin, docetaxel and irinotecan. A pharmacokinetics–pharmacodynamics (PK/PD) tumour model with eight resistance states is used as the simulation environment. The controller aims to minimi...

Articles
Alizade B, Hajipour A•
PubMed

Benign Growth, Malignant Protection? Insights into Benign Prostatic Hyperplasia and Prostate Cancer.

We read with great interest the recent review by Zarakowska et al [1] on the relationship between prostate cancer (PCa) and benign prostatic hyperplasia (BPH), which thoughtfully explores the roles of inflammation, oxidative stress, and epigenetics as common pathogenic links. The authors correctly highlight that chronic inflammation is a key factor in both conditions and cite epidemiological evidence suggesting that a diagnosis of BPH is associated with an increased risk of PCa incidence and mor...

Articles
Su PJ, Shao IH, Lin YH•
PubMed

Is Oral Anticoagulation an Independent Predictor of Mortality in STEMI and High-Risk NSTEMI Patients After Primary PCI? A Propensity Score-Matched Retrospective Analysis.

Background Managing STEMI and high‐risk NSTEMI‐equivalent patients on chronic oral anticoagulation (OAC) undergoing primary PCI poses competing ischaemic and bleeding risks. Methods This single‐centre retrospective study enrolled 604 consecutive STEMI/high‐risk NSTEMI patients undergoing primary PCI (2012–2023). OAC users (n = 100) were compared with propensity score–matched controls (n = 203). Primary endpoints included all‐cause mortality, bleeding, stroke, recurrent MI and rehospitalisatio...

Articles
Polat R, Polat F, Velibey Y, Bolca O, İpek G•
POR

What Patients Really Want: Re-Centering Primary Care on the Human Experience

by Aaron Medaris Modern primary care medicine is at a crossroads. While physicians juggle administrative burdens, time pressures, and complex chronic care, patients are increasingly vocal about what they value most in their medical encounters. Numerous surveys, including the Commonwealth Fund International Health Policy Survey , NEJM Catalyst Insights Council reports, and data from The Beryl Institute’s State of Patient Experience , consistently reveal that patient satisfaction and adhe...

Point of Care Testing
Aaron Medaris•
PubMed

International Brazilian Journal of Urology Congratulates the 2025 Best Reviewers.

In 2025 the International Brazilian Journal of Urology received the highest impact factor of his history (4.5) and this fact was possible because the serious peer review process of our Journal (1). In this year we received more than 600 papers. The peer review system is a very difficult process because is completely free. This process depends of the hard work of the experts in several topics reviewers by on the topic. The Editor-in-Chief would like to thanks all the reviewers and specially to th...

Articles
Favorito LA•
POR

Artificial Intelligence in Diabetes Care: Evolving Roles for the Primary Care Physician

by Adam Irvine, Staff Writer, Physicians Office Resource Diabetes care has long been a cornerstone of primary care practice. With nearly 38 million Americans living with diabetes and another 98 million with prediabetes, the majority of whom are managed outside of endocrinology settings, primary care physicians sit at the center of diabetes detection, management, and prevention. From early diagnosis and medication initiation to long-term monitoring, education, and coordination of multidiscipli...

Point of Care Testing
Adam Irvine•
POR

Preparing for the Respiratory Illness Season: Practical Steps for Primary Care, Pediatrics, and Urgent Care Practices

by Matt Baker, Staff Writer, Physicians Office Resource Each fall and winter, respiratory viruses place significant demands on outpatient medicine. Primary care physicians, pediatricians, and urgent care providers are often the first point of contact for patients experiencing cough, fever, congestion, and other respiratory symptoms. In 2025, the convergence of influenza, COVID-19, RSV, and other viral pathogens is expected to once again increase patient load, stretch staff capacity, and test...

Point of Care Testing
Matt Baker•