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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 217–228 of 2,098 articles

PubMed

Effectiveness of nurse-led hypertension interventions on retention, adherence, and blood pressure control among adults in low- and middle-income countries: A systematic review.

Background Hypertension affects more than 1.28 billion adults globally and remains the leading modifiable risk factor for cardiovascular disease, stroke, renal failure, and premature death. This burden is inconsistently distributed across Low- and Middle-Income Countries (LMICs), where nearly three-quarters of adults live with hypertension. This gap is largely driven by poor adherence and low retention. This systematic review aims to assess the effectiveness of nurse-led interventions on retent...

Articles
Yakob T, Suwanbamrung C, Le CN, Badacho AS, Saengow U•
PubMed

Long-term benefits of early obstructive sleep apnea treatment in infants with Down syndrome.

Purpose The Respire−21 study found that early obstructive sleep apnea (OSA) diagnosis and treatment is associated with improved neurocognitive and behavioral outcomes in infants with Down syndrome (DS) followed from 6 to 36 months of age (screened group) versus a control group receiving standard care at 36 months of age (standard care group). This follow-up study assessed whether these benefits persisted at 60 months of age and whether early OSA treatment influenced language and communication o...

Articles
Mircher C, Falquero S, Sacco S, Couloigner V, Amaddeo A, Ravel A, Montagutelli D, Prioux E, Toulas J, Marey I, Luscan R, Clert M, Martet D, Caillaud MA, De Sanctis L, Khirani S, Walti H, Fauroux B•
PubMed

Non-linear associations between parity and long-term risk of osteoporosis.

Summary Our findings suggest that although pregnancy and lactation are periods of physiological calcium loss, higher parity is not associated with an increased risk of postmenopausal osteoporosis; rather, it appears to confer a long-term protective effect. Purpose Osteoporosis is a significant public health burden. While parity induces transient bone loss, their long-term skeletal impact remains poorly understood. This study aimed to clarify the associations between parity, defined as the num...

Articles
Yuan W, Liao J, Tao L, Song H, Wang H, Huang J, He J, Liu H, Wu T, Zhou H, Zhang Y, Song C•
PubMed

Effectiveness and safety of lasmiditan and rimegepant in the acute migraine treatment: an indirect real-world comparison.

Aim Rimegepant and lasmiditan are effective acute migraine treatments, but real-world head-to-head comparative data are lacking. We aimed to compare their effectiveness and tolerability in clinical practice. Methods This post-hoc study indirectly compared two prospective, multicenter, real-world studies (GAINER and DART). Participants treated up to four migraine attacks with rimegepant 75 mg orally disintegrating tablets or lasmiditan 50 or 100 mg. Data were collected using an electronic diar...

Articles
Vaghi G, Iannone LF, Sebastianelli G, Piella EM, Corrado M, Romozzi M, De Santis F, Ornello R, Pistoia F, De Cesaris F, Burgalassi A, Coppola G, Silvestro M, Rainero I, Volta GD, Montisano DA, Guerzoni S, Prudenzano MP, Mascarella D, Avino G, Mampreso E, Valente M, Battistini S, Granato A, Albanese M, Trimboli M, Doretti A, De Icco R, Italian Headache Registry (RICe) Study Group•
PubMed

Molecular MRI Reveals Macrophage-Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer.

ABSTRACT Incomplete image‐guided ablation can promote local tumor progression by reshaping the residual tumor microenvironment toward immunosuppression, yet noninvasive biomarkers of this process remain limited. Here, a translational multiparametric PET/MRI strategy was developed to monitor macrophage‐associated microenvironmental remodeling after incomplete microwave ablation (iMWA) in orthotopic VX2 liver tumors. Twenty‐four tumor‐bearing rabbits were assigned to untreated control, early post...

Articles
He Y, Xu H, M M Rogasch J, Berndt N, Guo J, Schellenberger E, Häckel A, Heidemann L, Hesse F, Liu Y, Ramtke J, Beindorff N, Hofheinz F, Kader A, Mülleder M, Textoris-Taube K, Hamm B, Müller DN, Schmidt R, Hauptmann R, Traub H, Schannor M, Savic LJ•
PubMed

Sex-specific inbreeding depression of the life-history traits in Frankliniella occidentalis.

Abstract Inbreeding depression decreases the fitness of progeny resulting from mating between related individuals. The sex-specific response to inbreeding remains unknown in haplodiploid organisms, which have haploid males and diploid females. This research examines the consequences of inbreeding using 2 different inbreeding protocols: full-sib (brother–sister, BS) and maternal backcross (mother–son, MS) on life history, demographic variables, growth in population size, and morphological stabil...

Articles
Woldemelak WA•
PubMed

Association of Neuronal Cell Adhesion Molecule (NrCAM) Gene with Autism Spectrum Disorder in Indian Cohorts.

Background Autism spectrum disorder (ASD) is the most complex neurodevelopmental disorder with impairments in communication, social interaction and stereotyped behaviours. ASD has been found to increase immeasurably in India, with estimates ranging from 1 in 68 to 1 in 100 children. Genetically, more than 1,000 genes have been linked with ASD. Among them, the neuronal cell adhesion molecule (NrCAM) gene is one of the candidate genes and is important for its critical role in the development and...

Articles
Chandrakala E, Nagaraj K•
PubMed

Closing the loop: a needs-assessment informed model for embedding a non-allergist penicillin allergy de-labelling service in acute medicine, a quality improvement report.

Abstract Objectives To describe and evaluate a needs-assessment informed model for embedding a non-allergist penicillin allergy de-labelling (PADL) service within an Acute Medical Unit (AMU), including stakeholder experience. Methods A four-phase quality improvement project in one UK AMU, reported per SQUIRE 2.0. Phase 1: needs-assessment survey of 124 staff (pharmacists, doctors, nurses, immunology staff). Phase 2: a multidisciplinary team translated Phase 1 barriers into a PEN-FAST-guided...

Articles
Toner P, Glass A, Donnelly C, Garnett K, Mchaffie M, Quinn S, Hillen C, Mullan J, Mustafa YH, Maguire C, Faulkner S, Ng B, Brady A•
PubMed

Bile acid dysmetabolism and microbial dysbiosis coincide with Clostridioides difficile infection in pediatric inflammatory bowel disease.

Pediatric inflammatory bowel disease (IBD) patients are at increased risk for Clostridioides difficile infection. This review highlights bile acid dysmetabolism, driven by gut microbiota dysbiosis and reduced microbial production of secondary bile acids, as a key factor linking pediatric IBD to increased CDI susceptibility. We examine interactions among IBD, dysbiosis, bile acid metabolism, and C. difficile, and discuss emerging microbiome-based interventions aimed at restoring bile acid homeost...

Articles
Rowe JC, Winston JA•
PubMed

Bioengineering strategies for off-the-shelf, cell-based cancer immunotherapy.

Cancer immunotherapy has reshaped modern oncology by leveraging immune effector cells to recognize and eliminate malignant tissues. Among cell-based approaches, adoptive cell therapies, most prominently chimeric antigen receptor (CAR) T cells, have produced high response rates and deep remissions in several hematologic malignancies. Despite these clinical successes, broad deployment remains limited by the dominant autologous manufacturing paradigm, which is associated with high per patient cost,...

Articles
Barlow BR, Sandoval-Castellanos AM, Canter RJ, Kim J•
PLOS

Sex-specific correlates of Schistosoma haematobium infection in a rural Zambian setting: A pilot study focusing on immune and hematological factors

This study aimed to identify and compare the sex-specific immune, hematological, and environmental factors associated with Schistosoma haematobium infection in a rural Zambian setting. This community-based cross-sectional study enrolled participants from rural Zambia. Schistosoma haematobium infection was diagnosed microscopically from urine. Blood samples were analyzed for complete blood counts and cytokines via ELISA. Data were analyzed using sex-stratified logistic regression models in StatCr...

Articles
David Chisompola, Reggison Phiri, Emmanuel L. Luwaya, Martin Chakulya, Lukundo Siame, Bislom C. Mweene, Benson M. Hamooya, Joseph M. Chalwe, Joreen P. Povia, Sepiso K. Masenga•
PLOS

Adversarial robustness of deep learning-based thyroid nodule segmentation in ultrasound

Deep learning-based segmentation models are increasingly integrated into clinical imaging workflows, yet their robustness to adversarial perturbations remains incompletely characterized, particularly for ultrasound images. We evaluated adversarial attacks and inference-time defenses for thyroid nodule segmentation in B-mode ultrasound. Two black-box adversarial attacks were developed: (1) Structured Speckle Amplification Attack (SSAA), which injects boundary-targeted noise, and (2) Frequency-Dom...

Articles
Nicholas Dietrich, David McShannon•