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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 277–288 of 2,098 articles

PLOS

Profiles of mental health indicators among Ukrainian people recently bereaved in the context of the full-scale Russian invasion

Bereavement research has frequently focused on psychopathology, while comparatively less attention has been given to well-being as a component of mental health. This study is the first to examine mental health profiles based on ICD-11 Prolonged Grief (PG) symptoms, posttraumatic stress (PTS) symptoms, and well-being in a sample of Ukrainians bereaved during the full-scale Russian invasion. Participants were 290 adults (Mage = 34.3, SD = 9.1 years), who had lost a loved one on average 5.3 months...

Articles
Justina Pociūnaitė-Ott, Paul A. Boelen, Iryna Frankova, Iryna Norkina, Maria Luisa F. Rispa Hoyos, Lonneke I.M. Lenferink•
PLOS

Correction: Trends in non-pharmacological treatment for insomnia: A nationwide study

In the Funding statement, the project number for the Ministry of Trade, Industry and Energy (MOTIE, Republic of Korea) under the Technology Innovation Program is listed incorrectly. The correct project number is: Project No. 20018183.

Articles
Mingee Choi, Junbok Lee, Jeahyung Lee, Suonaa Lee, Eun Lee, Jaeyong Shin•
PLOS

Knowledge gap in vertebrate genetic diversity in a northern remanent of neotropical rainforest

Los Tuxtlas Biosphere Reserve is one of the last remaining areas of primary tropical rainforest in Mexico. This fragile ecosystem heavily reduced by human perturbations is part of the Mesoamerican hotspot. The reserve harbors many endemic species. Thus, identifying, cataloging, and studying the biodiversity of this ecosystem has been of utmost importance. A promising approach for fast species identification to assess biodiversity is the use of DNA barcoding techniques. However, these techniques...

Articles
David José Martínez Cano, Víctor Hugo Reynoso, María de Lourdes Vázquez-Cruz, Edyciel Jordán Alvarado-Robledo, Yesenia Ithaí Ángeles-López, Eugenia Zarza•
PLOS

A deep genetic structure phylogenomically frames the closest algal relatives of land plants

Discerning the nature of the last common ancestor of land plants (embryophytes) and algae allows to retrace the adaptations that ushered in the conquest of land by plants. For this, the closest streptophyte algal relatives of embryophytes hold key information. Albeit initially coming as a surprise due to their plain body plans, all major phylogenomic efforts have concluded that the Zygnematophyceae are the algal sisters to land plants. The Zygnematophyceae are the streptophyte algal class with t...

Articles
Maaike J. Bierenbroodspot, Cäcilia F. Kunz, Elisa S. Goldbecker, Maike Lorenz, Iker Irisarri, Thomas Pröschold, Tatyana Darienko, Jan de Vries•
PLOS

Risk of cardiovascular events and mortality associated with LDL and non-HDL cholesterol levels after statin initiation for primary prevention: A multiregional cohort study

Background: The cardiovascular and mortality benefits of achieving guideline-recommended concentrations of low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol with statins in primary prevention remain uncertain. Methods and findings: In this new-user cohort study, we used electronic healthcare databases from Hong Kong (HK), New Zealand (NZ) and the United Kingdom (UK) to identify 185,237 patients initiating statins between 1 January 2007 and 31 December 2012 (wit...

Articles
Joseph Edgar Blais, Ralph Kwame Akyea, William Harrison, Amy Hai Yan Chan, Wenfang Zhong, Stephen Franklin Weng, Kebede Abera Beyene, Wallis C. Y. Lau, Kenneth K. C. Man, Nadeem Qureshi, Esther Wai Yin Chan, Ian Chi Kei Wong, Jeff Harrison•
PLOS

Effects of music medicine on anxiety among primigravida mothers of preterm neonates: The CalM MOM randomised controlled trial protocol

Background: Preterm birth and Neonatal Intensive Care Unit (NICU) admission are significant stressors that heighten maternal anxiety. Although RCTs have reported that music-based interventions used alongside usual care (UC) are effective and low-cost in reducing maternal anxiety, evidence from India remains limited. Objective: Primary objective is to assess the impact of listening to recorded classical Indian Instrumental Saraswati Veena music (Ragas Kalyani and Hindolam) (30-minutes/day over 7-...

Articles
Bishnupriya Mukherjee, Tara Rajendran, Anjali Maria Augustine, Akshay Patil, Subham Kumar Mohanta, Nutan Kamath•
PLOS

Unveiling the neuroinflammatory potential of aspartame in Alzheimer’s disease: A comprehensive network toxicology and experimental validation approach

Aspartame, a widely used artificial sweetener, has raised significant concerns regarding its safety, especially in light of the rising incidence of Alzheimer’s Disease (AD). However, systematic investigations into aspartame’s potential neurotoxicity and its role in AD pathology remain limited. In this study, we employed an integrated approach combining network toxicology predictions, molecular docking, and in vitro validation to explore the neurotoxic mechanisms of aspartame in AD. By analyzing...

Articles
Dongyang Li, Xuejun Weng, Yijuan Huang, Dongni Yang, Shunhan Yao, Weihao Zheng, Xiaohong Jiang, Yilin Wei, Sheng Xu, Chunwei Wei•
PLOS

Transforming pandemic influenza antiviral stockpiling using a capacity-based approach: A modeling study

Background: Pandemic influenza preparedness in high-resource nations has traditionally relied on large antiviral stockpiles, typically targeting coverage for 25% of the population. This inventory-based benchmark focuses on cumulative disease burden but often overlooks the inelastic capacity of healthcare systems to manage acute surges. As multi-billion-dollar inventories reach expiration, we evaluated whether static stockpiles remain a viable strategy for preventing healthcare system collapse du...

Articles
Nir Gavish, Amit Huppert•
PubMed

Sex-based disparities in whooping cough prevalence in Sierra Leone: Evaluating World Health Organization Health Equity Assessment Toolkit data.

Abstract Background This study examines the trends and sex-based inequality in the prevalence of whooping cough in Sierra Leone, from 2000 to 2019. Methods We utilized national health records extracted from the WHO Health Equity Assessment Toolkit database to analysed age-standardized prevalence per 100 000 population and employed inequality measures: Difference (D), Population Attributable Fraction (PAF), Population Attributable Risk (PAR) and Ratio (R) to examine sex-based inequalities. R...

Articles
Osborne A, Sesay U, Ahinkorah BO•
PubMed

Gastrointestinal Kaposi Sarcoma as the Initial Presentation of Undiagnosed HIV Infection: A Case of Unexplained Anemia.

Kaposi sarcoma (KS) is an angioproliferative malignancy associated with human herpesvirus‐8 (HHV‐8) infection and is strongly linked to immunosuppression, particularly in the setting of human immunodeficiency virus (HIV). Although cutaneous involvement is the most common presentation, visceral disease—especially within the gastrointestinal (GI) tract—may occur and is frequently underrecognized due to its often asymptomatic or nonspecific clinical manifestations. We report the case of a 41‐year‐o...

Articles
Omar A, Zouein T, Salameh R, Zodeh K, Karam K, Aftimos G, Hani P•
PubMed

Low tumor burden follicular lymphoma: The state of the art.

Abstract Follicular lymphoma (FL) is the commonest indolent non‐Hodgkin lymphoma. Most patients present with advanced‐stage and are stratified by the Groupe d'Etude des Lymphomes Folliculaires (GELF) criteria into high or low tumor burden (LTB). Randomized trials in LTB FL demonstrated no overall survival advantage with immediate treatment compared to watchful waiting (WW). This led to the widespread practice of WW and the consideration of LTB FL as a single indolent continuum. However, LTB FL...

Articles
Hapgood G, Tobin J, Kridel R, Kahl B•
PubMed

Pulmonary Sarcoidosis Presenting as a Solitary Pulmonary Nodule With Probable Neurosarcoidosis: A Case Report.

ABSTRACT A 51‐year‐old woman presented with a solitary pulmonary nodule, hilar and mediastinal lymphadenopathy and progressive sensory disturbances. FDG‐PET demonstrated intense uptake in the pulmonary and hilar lesions, while spinal MRI showed thoracic cord enhancement. Lung cancer‐associated paraneoplastic neurological syndrome was initially suspected. Biopsies of the endobronchial lesion and a mediastinal lymph node revealed noncaseating granulomas without malignancy. Ocular involvement and...

Articles
Homochi M, Shirai T, Sato T, Mukai A, Tanaka T, Hashiba F, Masaki A, Naiki-Ito A, Takakuwa O, Kanemitsu Y•