Sign in Register

Clinical intelligence & editorial.

Advertisement

Advertisement

Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 337–348 of 2,098 articles

PubMed

Exaggerated blood pressure response to exercise: bridging the gap between evidence and guidelines.

An exaggerated blood pressure response to exercise (EBPR), also termed a hypertensive response to exercise, is a hyperdynamic phenotype in which blood pressure (BP) rises disproportionately during graded physical exertion. Over more than 3 decades, EBPR has been linked to incident hypertension, masked hypertension, subclinical target-organ damage, and adverse cardiovascular outcomes, largely independent of resting BP. Despite this consistent body of evidence, EBPR has yet to be formally recogniz...

Articles
Cho IJ•
PubMed

Post-donation systolic blood pressure trajectories after living kidney donation and paired recipient outcomes: a nationwide prospective cohort study from KOTRY.

Background Donor nephrectomy increases susceptibility to hypertension. However, post-donation systolic blood pressure (SBP) trajectories in living donors remain poorly characterized and their implications for paired kidney transplant recipients (KTRs) uncertain. Methods We analyzed 3,844 living donor–recipient pairs from a nationwide, multicenter, prospective, cohort. Longitudinal SBP measurements of donors after donation were analyzed using latent class mixture modeling to identify SBP traje...

Articles
Yoon HE, Cheong HK, Choi SJN, Shin S, Han S, Yang J, Kim MS, Lee JY, Lee YH, Hwang HS•
PubMed

Optimizing aprocitentan dosing in elderly Chinese patients with resistant hypertension: a PBPK/PD-circadian rhythm modeling study.

Background Aprocitentan is a dual endothelin receptor antagonist for resistant hypertension (RH), but its optimal use in elderly Chinese patients remains unclear. This study aimed to develop an integrated physiologically based pharmacokinetic (PBPK)/pharmacodynamic (PD)-circadian rhythm model to suggest precision dosing and administration-time optimization in this special population. Methods A PBPK model was developed using published clinical pharmacokinetic data and linked to a direct-effect...

Articles
Jia M, Xu Z, Qian F, Zhang L, Xue H, Zhu X, Xiang X, Lee SWH, He Q•
PubMed

Prevalence of Suspected Obstructive Sleep Apnea Among Patients With Chronic Cough and Relatively Low BMI.

Background/Aim Recent studies have suggested an association between chronic cough and obstructive sleep apnea (OSA). This study aimed to estimate the prevalence of suspected OSA and describe associated clinical characteristics among Japanese adults with chronic cough. Patients and Methods Outpatients with chronic cough were recruited from three Japanese institutions between March 2023 and February 2025. Eligible participants were ≥20 years old with a cough lasting >8 weeks. Overnight home sle...

Articles
Iwamoto N, Katsurada N, Okamura K, Nishiuma T, Takayasu M, Nagano T•
PubMed

Resting-State EEG Spectral Power in Young Adults With Generalized Anxiety Disorder and Self-Reported Habitual Short Sleep: A Case-Control Study.

ABSTRACT Background Generalized anxiety disorder (GAD) and insufficient sleep frequently co‐occur during early adulthood, yet resting‐state electroencephalographic (EEG) evidence in this population remains limited. The present study aimed to characterize resting‐state EEG spectral power in young adults with GAD who also reported habitual short sleep, compared with healthy controls. Methods This exploratory case‐control study included 56 university students: 28 participants with GAD and self‐...

Articles
Wang M, Wu L, Shi C, Gao J, Zhang M, Jiang H, Yuan Y, Wu L, Yin H, Gao Y, Fu W, Chen X•
PubMed

Association Between Pre-Pregnancy and First-Trimester Hematological Parameters and HELLP Syndrome.

ABSTRACT Aim To investigate whether hematological biomarkers prior to pregnancy and during the first trimester are associated with subsequent development of HELLP syndrome. Methods This case–control study was based on laboratory data from 2010 to 2023 in the Copenhagen Capital Region. Pregnant women were identified through first‐trimester biochemical screening. A total of 216 women with HELLP syndrome were matched to 4302 controls according to maternal age and date of first‐trimester biochem...

Articles
Sundberg AJS, Turan GI, Jørgensen HL, Klok FR•
PubMed

Community Transmission of Pneumonic Plague, Fenoarivobe, Madagascar, 2022.

The results of an outbreak investigation of pneumonic plague conducted in the plague-endemic district of Fenoarivobe, Madagascar, revealed a familial cluster of plague. Transmission was aided by intrahousehold contact or gatherings and was amplified by delayed plague treatment, highlighting the need for early diagnosis and rapid initiation of appropriate therapy.

Articles
Randrianasolo L, Rakotoarimisa R, Rahajandraibe S, Harimanana A, Ranoelison N, Randriamanantsoa MG, Andrianarisoa BA, Rahelinirina S, Razafimbia V, Raherinandrasana A, Rakotomanana F, Vololoniaina MA, Randremanana RV, Rajerison M•
PubMed

RETRACTION: Tristetraprolin Attenuates Brain Edema in a Rat Model of Cerebral Hemorrhage.

RETRACTION: P. Li, J. Zhang, X. Li, and H. Gao, “Tristetraprolin Attenuates Brain Edema in a Rat Model of Cerebral Hemorrhage,” Brain and Behavior 9, no. 3 (2019): e01187, https://doi.org/10.1002/brb3.1187. The above article, published online on 06 February 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Amanda Bischoff‐Grethe; and Wiley Periodicals, LLC. The retraction has been agreed upon following concerns raised by...

Articles
PubMed

A Multimodal Neuroimaging Study of Hyperlipidemia-Induced Abnormal Spontaneous Brain Activity and Cognitive Decline.

ABSTRACT Objective To investigate multidomain cognitive performance in older adults with hyperlipidemia and its associations with alterations in spontaneous brain activity and functional connectivity (FC). Methods A total of 104 participants were recruited, comprising 50 hyperlipidemia patients and 54 healthy controls. Comprehensive psychological assessments were conducted, and resting‐state functional magnetic resonance imaging (rs‐fMRI) data were collected from both groups. Amplitude of lo...

Articles
He JH, Wu JJ, Meng FL, Xiang YT, Huang RR, Zheng MX, Ma J, Xu JG•
PubMed

Surgical Management of Pediatric Nodular Lymphocyte-Predominant Hodgkin's Lymphoma: A Systematic Review of Surgical Outcomes and Case Report.

ABSTRACT Introduction Nodular lymphocyte‐predominant Hodgkin lymphoma (NLPHL) is a rare subtype, representing 5% of Hodgkin lymphoma cases. It is distinguished by lymphocyte‐predominant cells expressing CD20 and CD79a but not CD15 and CD30. Pediatric NLPHL affects primarily males aged 4–17, often presenting with localized lymphadenopathy and favorable outcomes. NLPHL's distinct pathology makes treatment optimization critical. Long‐term risks of chemotherapy and radiotherapy have led to interes...

Articles
Singh B, Raynor EM•
PubMed

Anti-TNF Therapy Is Associated With Browning- and Immune-Related Changes in Creeping Fat in Crohn's Disease.

ABSTRACT Background Creeping fat (CrF) in Crohn's disease (CD) is a metabolically active perilesional adipose tissue involved in intestinal inflammation. Whether biological therapies modify its browning‐associated phenotype remains largely unexplored. We investigated whether anti‐TNF treatment is associated with changes in browning‐, mitochondrial biogenesis‐ and immune‐related pathways in CrF and whether similar molecular changes occur following ex vivo infliximab exposure. Methods Two inde...

Articles
Monfort-Ferré D, Ginés I, Cepero C, Cabré L, Caro A, Menacho M, Gené M, Garcia M, Lahoz MDC, Mañas MJ, Martí M, Tarzán A, Suau R, Ferreres J, Manyé J, Serena C•
PubMed

A Nomogram for Individualized Frailty Identification in Older Inpatients with Schizophrenia: Development and Internal Validation.

Objective To investigate the prevalence and associated factors of frailty among older inpatients with schizophrenia, and to develop and internally validate a nomogram for individualized identification of current frailty. Methods Between May and September 2025, we enrolled 279 older inpatients with schizophrenia (aged ≥60 years) from a tertiary hospital in Guangzhou using convenience sampling. Data included electronic medical records, patient interviews, and the Fried frailty phenotype assessm...

Articles
Liu X, Yan X, Zhou H, Liu C, He X, Tang Q, Yuan L, Yang S, Zheng T, Zhang C•