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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 397–408 of 2,098 articles

PubMed

Longer Sleep Duration Predicts Progression to Bipolar or Psychotic Disorders in Youth Accessing Early Intervention Mental Health Services.

ABSTRACT Background While growing evidence implicates sleep‐wake and circadian rhythm disturbances (SCRDs) in the onset and course of mood and psychotic disorders, longitudinal studies using objective measures are limited. This clinical cohort study examined whether actigraphy‐derived SCRDs (sleep duration, timing, and efficiency) predicted transition to (i) any full‐threshold mental disorders; and then specifically; (ii) full‐threshold bipolar or psychotic disorders; or (iii) other full‐thres...

Articles
Carpenter JS, Crouse JJ, Varidel M, Tonini E, Shin M, Zmicerevska N, Nichles A, Hermens DF, Merikangas KR, Scott EM, Hickie IB, Iorfino F•
PubMed

JAK1 Inhibitors for Eczematous Eruptions Following Anti-IL-17A Therapy in Psoriasis: A Case Series.

Background Eczematous eruption (EE) is a paradoxical adverse event during interleukin-17A (IL-17A) inhibitor therapy for psoriasis and may require modification or discontinuation of biologic therapy. However, evidence guiding its management remains limited. Methods We retrospectively reviewed 13 patients with psoriasis who developed EE during IL-17A inhibitor therapy and subsequently received selective Janus kinase 1 inhibitors (JAK1i; upadacitinib, n=11; abrocitinib, n=2). Results JAK1i tr...

Articles
Zhang L, Wu J, Zheng J, Chen L, Wang Y, Li X•
PubMed

Exercise capacity in patients with psoriasis assessed by cardiopulmonary exercise testing: a case-control study.

Background Psoriasis is a systemic inflammatory disease associated with cardiovascular and metabolic comorbidities. Although reduced physical activity is frequently reported in these patients, objective data on physiological exercise capacity remains limited. Objective To evaluate exercise capacity in patients with psoriasis using Cardiopulmonary Exercise Testing (CPET), the gold standard method, and compare the results with those of healthy controls. Methods This cross-sectional study incl...

Articles
Baykal Şahin H, Ferhatosmanoğlu A, Baykal Selçuk L•
PubMed

Effects of intra-articular micro-fragmented adipose tissue alone or combined with hyaluronic acid or collagen on cartilage degeneration and oxidative stress in an experimental rabbit osteoarthritis model.

Background Osteoarthritis is a prevalent, debilitating, progressive joint disease characterized by articular cartilage degradation, synovial inflammation, and subchondral bone remodeling. This study evaluated the local structural and systemic oxidative stress effects of intra-articular human-derived micro-fragmented adipose tissue (MFAT), administered alone or combined with hyaluronic acid (HA) or injectable collagen (COL), in an experimental rabbit osteoarthritis model. Methods Twenty-four r...

Articles
Adam AO, Benea HRC, Gherman LM, Oltean-Dan D, Apostu D, Gheban D, Crișan M•
PubMed

Cost-effectiveness analysis comparing advanced hybrid closed-loop automated insulin delivery with multiple daily insulin injections and continuous glucose monitoring in adults with type 1 diabetes in Japan.

ABSTRACT Aim The use of automated insulin delivery systems, including the MiniMed™ 780G advanced hybrid closed‐loop system, has been shown to improve glycemic management in people with type 1 diabetes (T1D). The aim was to assess the cost‐effectiveness of the MiniMed 780G system versus multiple daily injections (MDI) of insulin in combination with continuous glucose monitoring (CGM) in the management of people with T1D with elevated HbA1c levels in Japan. Methods Modeling was performed using...

Articles
Kodani N, Saltik AZO, Tone A, Field M, Pollock RF, Hill M, Hirota Y, de Portu S•
PubMed

Cardiac remodeling, autonomic parameters, and clinical factors associated with obstructive sleep apnea: a case-control study.

Background Obstructive sleep apnea (OSA) is associated with substantial cardiovascular morbidity through mechanisms involving intermittent hypoxia, sympathetic activation, oxidative stress, and progressive cardiac remodeling. The present study aimed to comprehensively evaluate clinical characteristics, echocardiographic abnormalities, autonomic function, and independent factors associated with OSA in a case-control population. Methods This observational, case-control study included 108 adults...

Articles
Bercian CVZ, Măgureanu DC, Pop RM, Procopciuc LM•
PubMed

Letter to the Editor Regarding "Physical Performance Continues to Improve After Surgery for Sciatica, Exceeding Recovery Periods of Physical Capacity and Patient-Reported Outcomes: Multicenter Prospective Observational Study".

To the Editor, We read with great interest the recent study by Ziga et al. [1], which demonstrated that smartphone-derived step counts continue to improve up to 6 months after lumbar surgery for sciatica, diverging from the earlier plateau observed in traditional patient-reported outcome measures and objective functional tests. This study underscores the value of real-world activity monitoring in capturing recovery processes that extend beyond clinic-based assessments. However, several methodo...

Articles
Huang D, Lin M, Dong J•
PubMed

Reply to Letter to the Editor Regarding "Physical Performance Continues to Improve After Surgery for Sciatica, Exceeding Recovery Periods of Physical Capacity and Patient-Reported Outcomes: Multicenter Prospective Observational Study".

We thank the authors of the letter for their insightful comments and interest in our study, “Physical Performance Continues to Improve After Surgery for Sciatica, Exceeding Recovery Periods of Physical Capacity and Patient-Reported Outcomes: Multicenter Prospective Observational Study.” [1] The points raised offer an excellent opportunity to clarify the methodological underpinnings and clinical interpretations of our findings. 1. Magnitude of Step Count Trajectories and Cohort Characteristics...

Articles
Ziga M•
PubMed

Recurrent respiratory papillomatosis juvenile: a retrospective analysis at Hospital Santo Antônio.

Objective To describe the profile of patients with Recurrent respiratory papillomatosis juvenile treated at a Brazilian tertiary referral center, including disease severity assessed with the Derkay staging system. Methods This retrospective observational case series included patients younger than 18 years with histopathologically confirmed who underwent laryngeal surgery and outpatient follow-up. Medical records from January 2014 to December 2025 were reviewed. Demographic, clinical, surgical...

Articles
Barbosa PB, Lopes DO, Amorim AM, Cunha GB, Almeida TS, Matos F•
PubMed

Population attributable mortality associated with respiratory viruses in Ontario, Canada: a population-based ecological analysis.

Summary Background Respiratory viruses are major contributors to population mortality, but cause-of-death coding undercounts their impact. Ecological regression linking viral circulation to mortality fluctuations can address this. We estimated the population attributable fraction (PAF) of mortality associated with influenza A and B, respiratory syncytial virus (RSV), and SARS-CoV-2 in Ontario, Canada, over 1993–2025, across the pandemic transition. Methods We analysed monthly all-cause morta...

Articles
Fisman DN, Grima AA, Wilson NJ, Mann S, Tuite AR, Lee CE•
PubMed

Altered sensorimotor-occipital network topology in chronic insomnia: A graph-theoretical and edge-wise resting-state fMRI analysis.

Objective The multi-level network aberrations in chronic insomnia (CI) and their neurobiological underpinnings remain elusive. Here, we applied graph-theoretical, edge-wise, and modular analyses to resting-state fMRI data to characterize systems-level functional network reorganization in CI patients. Methods Resting-state fMRI was acquired from CI patients and healthy controls (HCs). Whole-brain functional networks were parcellated using the Dosenbach-160 atlas, and then graph-theoretical, ed...

Articles
Wen Z, Kong Y, Wen Y, Zhang H, Long L•
PubMed

The hypertension-NVU-cognition Axis: Mechanisms and interventions.

Midlife hypertension is a major modifiable risk factor for Alzheimer's disease, but the specific molecular pathways through which it contributes to cognitive decline—pathways that are partially independent of, and interact with, amyloid-β pathology—are not fully elucidated. This review synthesizes and elaborates the “Hypertension-NVU-Cognition” axis, building on the established cerebrovascular biology, neurovascular unit, cerebral small vessel disease (CSVD), and vascular cognitive impairment (V...

Articles
Tao Z•