Clinical intelligence & editorial.

PLOS

Reporting of research priorities in migraine clinical practice guidelines still need improvement—A methodological analysis

Objectives: To systematically analyze the content and format of research priorities in clinical practice guidelines (CPGs) for migraine, providing a methodological guidance for future guideline developers and researchers. Methods: This methodological systematic analysis involved searching six databases (Embase, PubMed CNKI, VIP, CBM and Wanfang) and the official websites of 39 authoritative organizations, including headache societies, neurology associations, and guideline development bodies. Ext...

Articles

Xuejian Yin, Yingdi Liao, Zhuo Ye, Yiyun Zhao, Shiyu An, Riai Tang, Qinyan Li, Shuting Yang, Yuze Sun, Yicheng Gao, Kai Yuan• October 30, 2026

PLOS

Nurse-Led treatment strategy based on asthma score and oxygen requirement in children with acute reversible bronchoconstriction: A randomised controlled non-inferiority trial

Objective: The Childhood Asthma Score (CAS) does not fully account for oxygen therapy in children with acute reversible bronchoconstriction (ARB), thus the CAS O2 was developed. Our aim was to assess effectiveness and safety of the CAS O2 treatment protocol compared to the CAS protocol. Design: Multicentre, open-label, randomised, non-inferiority trial. Setting: Two Dutch teaching hospitals with general paediatric wards. Patients: Children 2–18 years admitted with ARB, requiring supplemental oxy...

Articles

Sam Louman, Britt Foreman, Lidy van Lente, Richard Kop, Laura Postma, Mark Jan Ploegstra, Annemie L. M. Boehmer, Arvid W. A. Kamps• October 30, 2026

PubMed

Operationalising a Comprehensive Lactation Management Centre in a Tertiary NICU in North India: A Retrospective Implementation Study With Before-After Comparison of Breastfeeding and Counselling Coverage.

Background: Feeding practices in neonatal intensive care units (NICUs) are often compromised by limited lactation support and mother-infant separation. A Comprehensive Lactation Management Centre (CLMC) integrates counselling, bedside lactation assistance and donor human milk banking within the NICU. Evidence on the real-world operationalisation of such centres in tertiary care institutions in India remains limited. This study describes the operationalisation of a CLMC in a tertiary NICU and eva...

Articles

Sharma A, Kashyap A, Pandey V, Kumar Singh A, Sharma M, Kumar A• October 30, 2026

PubMed

Plague - an infectious disease challenge far from resolved.

Recently, Sidhu et al.[1] deciphered a molecular mechanism of evolutionary adaptation of Yersinia pestis (Y. pestis), the causative agent of plague, to decreasing density and interconnection of rodent host populations during the three historically documented plague pandemics. It consists of an incomplete depletion of the plasmid-located virulence gene pla, which mediates the conversion of plasminogen to plasmin and thus the lysis of fibrin clots, facilitating bacterial dissemination from the inf...

Articles

Frickmann H, Wiemer DF, Schmidt-Chanasit J• October 30, 2026

PubMed

Risk Factor Profiles and Clinical Outcomes: A 6-Month Longitudinal Study on Rehospitalization Rates in Patients with Chronic Heart Failure.

Objective To evaluate rehospitalization rates and identify modifiable risk factors in chronic heart failure (CHF) patients enrolled in an optimal management and treatment program. Methods A prospective cross-sectional study with longitudinal follow-up was conducted on 163 patients diagnosed with CHF patients (Framingham criteria) at an international hospital model in Vietnam from January 2022 to November 2023. Clinical, behavioral, and comorbid factors were analyzed over 6 months. Results T...

Articles

Pham LT, Chu SD, Tran MT• October 30, 2026

PubMed

Depressive Symptoms and 6-Year KCCQ Health Status in Chronic Heart Failure: Findings From the Cognition.Matters-HF Cohort.

Background Long-term disease-specific health status trajectories in ambulatory chronic heart failure (HF) are incompletely characterized, and the contribution of depressive symptoms remains uncertain. Objectives The objectives of the study was to characterize 6-year Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OSS) trajectories and distinguish persistent and visit-specific depressive symptom associations with health status. Methods In the prospective Cognition.Matter...

Articles

Winkelmann P, Wissel S, Cejka V, Homola G, Morbach C, Sell R, Frantz S, Wuttke A, Pham M, Stoll G, Störk S, Frey A, Traub J• October 30, 2026

PubMed

Hiatal Hernia and Conclusive Gastroesophageal Reflux Disease: Size Matters.

Background/Aims The Lyon Consensus considers hiatal hernia (HH) as a supportive metric for the diagnosis of gastroesophageal reflux disease (GERD) when evidence is inconclusive; however, HH size is not taken into consideration. We aimed to correlate HH size with conclusive evidence of GERD from multichannel intraluminal impedance and pH monitoring (MII-pH) and upper endoscopy. Methods We analyzed a retrospective consecutive cohort of patients with suspected GERD with and without HH on high-re...

Articles

Hernández JS, Hani AC, Muñoz OM, Garcia JP, Cañadas RA, Ávila FA, Arias F, Gyawali CP• October 30, 2026

PubMed

Dynamic Changes in Small-Intestinal Bacterial Overgrowth Following Stricture-Directed Interventions in Patients With Crohn's Disease: A Prospective Cohort Study.

Background/Aims Prospective data regarding small-intestinal bacterial overgrowth (SIBO) in patients with Crohn’s disease (CD) are limited, and the influence of small-bowel strictures on SIBO as well as the effects of stricture-directed interventions remain unclear. Methods Patients with CD were classified into stricture and non-stricture groups on the basis of the findings of double-balloon enteroscopy or cross-sectional imaging. Healthy controls (HCs) were included. All participants underwen...

Articles

Igarashi T, Tominaga K, Yokoyama K, Wakabayashi T, Yamazaki H, Yamazaki S, Kojima Y, Kawata Y, Takahashi K, Sato H, Sakamaki A, Terai S• October 30, 2026

PubMed

Impact of BMI on Ramadan fasting in individuals with type 2 diabetes mellitus: Insights from the DaR Global Surveys 2020-2022.

Introduction Fasting during the holy month of Ramadan is a central religious practice for Muslims worldwide, including individuals living with type 2 diabetes mellitus (T2DM). Managing diabetes during prolonged fasting presents significant clinical challenges, particularly balancing glycemic control and preventing complications such as hypoglycemia. The body mass index (BMI) is a widely used surrogate marker for metabolic status and may significantly influence the physiological response and tol...

Articles

Alzaman N, Habib M, Uddin F, Rosandi R, Shaikh S, Hassanein M• October 30, 2026

PubMed

Association of 14 matrix metalloproteinases and 4 tissue inhibitors of metalloproteinases on ankylosing spondylitis: A bidirectional Mendelian randomization study.

Observational studies link matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) to ankylosing spondylitis (AS), but causality is uncertain. We performed a bidirectional, 2-sample Mendelian randomization (MR) analysis using genetic variants to assess causal relationships between genetically predicted circulating levels of 14 MMPs and 4 TIMPs and AS risk, and to evaluate reverse causation. Genetic instruments for circulating MMPs and TIMPs were derived from a large...

Articles

Sun X, Li G, Zhao H, Wang Y• October 30, 2026

PubMed

Real‑World Evaluation of Omadacycline Switch Therapy for Multidrug‑Resistant Bacterial Pneumonia in Patients with Tigecycline Intolerance.

Background Tigecycline represents a critical therapeutic option for multidrug‑resistant infection, however, its clinical utility is limited by adverse drug reaction (ADR), particularly hypofibrinogenemia and thrombocytopenia. This study aimed to evaluate the clinical characteristics and outcomes among patients with MDR pneumonia in a real‑world clinical setting. Methods This single-center, retrospective study included hospitalized adults with pneumonia who were switched from tigecycline to om...

Articles

Zhu Y, Liang L, Zhang J, Ju Y• October 30, 2026

PubMed

Selenium Nanoparticles in Atherosclerosis and Non-Alcoholic Fatty Liver Disease: A Comprehensive Review of Therapeutic Mechanisms, Targeted Delivery, and Translational Prospects.

Abstract Selenium nanoparticles (SeNPs) have emerged as a promising nanomaterial in biomedicine due to their unique physicochemical properties. This review summarizes the research and progress of SeNPs in atherosclerosis (AS) and non-alcoholic fatty liver disease (NAFLD). In the AS model, CS-SeNPs (40 μg Se/kg/day, 10 weeks) significantly reduced the area of aortic plaques (25.1%). Similarly, PM@Se/Rb1 NPs significantly reduced the plaque area of the aortic arch (85→20%) and aortic root (79→26....

Articles

Chen K, Wang SZ• October 30, 2026