Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Cancer progression is driven by complex interaction among malignant cells, stromal components, and tumor-infiltrating immune cells, which together define the tumor immune microenvironment (TIME). Tumor cells evade immune surveillance by impairing the cytotoxic CD8+ T-cell function and promoting immunosuppressive cell populations including regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells. Although immune checkpoint blockade and adoptive T-cell therapy have ad...
Background Osteoarthritis (OA) is a common musculoskeletal disorder associated with pain, functional limitation and disability. In sub-Saharan Africa, health-seeking behaviour (HSB) is influenced by beliefs, health literacy, access to services and healthcare systems, yet this evidence has not been synthesised. Objectives To map and describe evidence on HSBs of people with osteoarthritis in sub-Saharan Africa, identify influencing factors, and highlight implications for physiotherapy practice...
Osteoarthritis
Nadasan T, Olagbegi O, Ntshembeni S, Ndwandwe B, Mabaso S, Govender L, Abraham R•
Abstract Tau phosphorylation is essential for early brain development but is also central to Alzheimer’s disease pathogenesis, suggesting an antagonistic pleiotropy model in which the same biology is beneficial early in life and harmful in ageing. Here, we investigate whether healthy term newborns exhibit higher concentrations of multiple phosphorylated tau species in plasma and compare their profiles against older adults and Alzheimer’s disease patients. In this multicentre study, we used the...
Alzheimer’S Disease
Gonzalez-Ortiz F, Kirsebom BE, Santos C, Arslan B, Gundersen JK, Kvartsberg H, Sävman K, Turton M, Harrison P, Coley Gleerup HS, Frederiksen KS, Hasselbalch SG, Simonsen AH, Fladby T, Barreto Henriksson H, Frandberg S, Hellström A, Groenendaal F, Nafash MN, Klaus EN, Zeng X, Karikari TK, Zetterberg H, Sjöbom U•
Purpose: A proportion of patients with systemic lupus erythematosus (SLE) present with subclinical low-level proteinuria at initial diagnosis that does not meet the formal classification criteria for lupus nephritis (LN). This study aimed to investigate the association between low-level proteinuria at SLE onset and the risk of developing proteinuria-predominant LN. Patients and methods: This was a retrospective cohort study using medical records of patients newly diagnosed with SLE from Fujian M...
Background: Serial ultrasound measurements may help characterize muscle wasting in critically ill patients. The flexor carpi ulnaris (FCU) is a superficial forearm muscle that may provide an additional assessment site. We described longitudinal FCU and biceps brachii (BB) cross-sectional area (CSA) changes and explored between-muscle differences and clinical associations. Methods: This prospective two-center observational study enrolled 23 intensive care unit (ICU) patients; 20 were included in...
Ischemic heart disease remains the leading cause of mortality worldwide. Its diagnosis largely relies on detecting dynamic changes in the ST segment of the electrocardiogram (ECG). However, alterations in other ECG waves and intervals have also been reported. One factor that is often overlooked is the presence of a prior myocardial infarction and its influence on the myocardial response to a new ischemic event. This study aimed to quantify the magnitude and temporal dynamics of ECG changes durin...
Ecg
Jimena Rodríguez-Carbó, Ana Mincholé, Esther Pueyo•
Following the publication of this article, the corresponding author made PLOS aware that the Ethics statement in the Methods section of [ 1 ] is incorrect and that the work reported in [ 1 ] was not supported by a valid protocol approval. A representative of Merrimack College stated that a valid Institutional Animal Care and Use Committee (IACUC) approved protocol covering the experiments in [ 1 ] does not exist, that approval from an external IACUC was not sought, and therefore that the Ethics...
Background: Post‑stroke fatigue (PSF) affects approximately 50% of stroke survivors and is one of the most common and disabling post‑stroke sequelae. Digital and technology‑enabled approaches have attracted increasing attention in the field of stroke rehabilitation, including mobile health applications (mHealth), wearable devices, virtual reality (VR), remote rehabilitation, artificial intelligence (AI), and neuromodulation technologies. However, no comprehensive scoping review has systematicall...
Photophobia encompasses a continuum of light-induced experiences from mild discomfort to overt pain and intolerance, yet clinical tools rarely quantify these distinctions, leaving many patients undiagnosed and untreated. This study employed the Ocular Photosensitivity Analyzer (OPA), a compact instrument for quantitative sensory testing (QST) with light, to investigate three perceptual levels in healthy adults: visual photosensitivity discomfort threshold (VPDT), visual photosensitivity pain thr...
Pain
Nathan Goturi, Cameron Talbert, Nicholas Pondelis, Mariela C. Aguilar, Alex Gonzalez, Cornelis Rowaan, Heather Durkee, Jean-Marie Parel, Vanda Faria, Eric Alan Moulton•
Breast cancer (BC) represents the most prevalent malignant tumor among women globally, with its pronounced heterogeneity presenting significant challenges for precision diagnosis and treatment. Aberrant lipid metabolism, particularly the ratio of low-density lipoprotein to high-density lipoprotein (LHR), has garnered considerable interest in relation to BC development and progression. Nevertheless, the association between LHR and clinicopathological characteristics remains inadequately explored....
Menopause
Lei Dong, Can Liu, Lixin Li, Xiaotong Zhang, Wei Xu, Gaosai Dai•
Attention deficit hyperactivity disorder (ADHD) is associated with various traits that influence individuals’ experiences at work. While some may be experienced as challenging (e.g., when differences in executive function impact time management), others can be more positive (e.g., when curiosity motivates exploration and discovery). Plausibly, academia is a work environment where these positive aspects should be valued. However, ADHD is still often viewed from a medicalised perspective in workpl...
Adhd
Lorna G. Hamilton, Anusha V. Ramji, Mahmoud Elsherif, Steven K. Kapp, Justin Sulik•
Attention deficit hyperactivity disorder (ADHD) is a comorbidity affecting 12%–29% of individuals with epilepsy, significantly impacting learning, psychosocial development, behaviour, and quality of life. Moreover, ADHD and epilepsy share a bidirectional relationship. Although methylphenidate has been proven effective in alleviating ADHD symptoms, its use remains limited in individuals with epilepsy due to outdated concerns—dating back over 20 years—that psychostimulants could increase seizure f...
Attention-Deficit Hyperactivity Disorder
Soto Insuga V, Russi ME, González Alguacil E, López Pisón J, Aguilera Albesa S, Málaga Dieguez I, Fons C•
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