Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Background: Stroke remains a leading cause of long-term disability worldwide, with a substantial proportion of survivors experiencing persistent limitations in functional mobility. Although many individuals regain the ability to walk in structured clinical environments, only a minority achieve independent community ambulation due to cognitive–motor interference (CMI). The subacute phase is characterized by heightened neuroplastic potential and responsiveness to rehabilitation. Dual Task-Oriented...
Osteoporosis is a progressive skeletal disorder characterized by reduced bone mineral density and increased susceptibility to fractures, making early diagnosis essential for effective clinical intervention and long-term patient management. Recent advances in artificial intelligence have demonstrated significant potential for automated bone disease assessment using medical imaging modalities. In this study, a unified deep learning framework, termed OsteoNet-X, is proposed for automated osteoporos...
Introduction: The COVID-19 pandemic significantly affected physical activity and lifestyle, potentially increasing Body Mass Index (BMI) and obesity risk. We examined changes in BMI and obesity across Pre-Pandemic, Pandemic Peak, and Peri-Pandemic periods and identified sociodemographic correlates. Methods: We analyzed longitudinal electronic health record data from the All of Us Research Program for adults ≥18 years with at least one BMI record in each period (N = 38,632). Periods were defined...
Obesity
Abdul-Hanan Saani Inusah, Huiyi Xia, Atena Pasha, Zhenlong Li, Andrew T. Kaczynski, Xiaoming Li, Shan Qiao•
Cardiovascular diseases (CVDs) are a significant cause of morbidity and mortality worldwide, with lifestyle modification being a cornerstone in their management. However, qualitative evidence on the influences that facilitate or hinder lifestyle modification practices among patients attending cardiac clinics in Tanzania remains limited. Understanding these influences is important for designing feasible, context-appropriate cardiovascular risk-reduction interventions. This study aimed to explore...
Cardiovascular
Gladness N. Mkawe, Benedicto Mgala, Neema Mawi, Salome E. Buluba, Menti Ndile, Khadija Malima, Edith Tarimo, Fatina B. Ramadhani•
Background: Low back pain is the leading cause of disability worldwide. Although numerous treatment approaches are recommended by international clinical guidelines, there is still limited understanding of which interventions provide the best value for money. We aimed to critically appraise and summarise the evidence on the cost-effectiveness and costs of interventions endorsed in recent guidelines to manage low back pain (LBP), compared to usual care. Methods and findings: We searched 10 electro...
Back Pain
Stephanie Mathieson, Martin Underwood, Muhammad Ibrahim, Zhilin Hua, Zhaohua Zhu, Paulo H. Ferreira, Hema Mistry, Emily R. Atkins, Jocelyn L. Bowden, Jillian P. Eyles, Andrew M. Briggs, David J. Hunter, Manuela L. Ferreira•
Objective: Problematic micro-drama use (PMDU) has received increasing attention as micro-dramas have become widely consumed among young adults in China. This study examined the associations between academic stress and PMDU among Chinese university students, explored which dimensions of academic stress were uniquely associated with PMDU, and examined the associations between PMDU and loneliness, anxiety symptoms, and depressive symptoms. Methods: A cross-sectional online survey was conducted amon...
An increasing number of households in the United States keep backyard poultry, including small hobby flocks, or purchase eggs from backyard poultry farmers. Concerns about rising grocery prices and a growing interest in homesteading have driven a surge in poultry-related sales. Some research has been conducted to understand the prevalence of zoonotic bacteria and antimicrobial resistance of the backyard environment; however, with the expansion of backyard hobby flocks and increasing availability...
Antibiotic
Sarah Tong, Grace Faulkner, Sarah Rhea, Annette Greer, Emily S. Bailey•
Background: Brain-derived neurotrophic factor (BDNF) is a key mediator of neuroplasticity and has been associated with disease progression in multiple sclerosis (MS). While aerobic exercise is consistently linked to BDNF modulation, the specific contribution of isolated resistance training (RT) remains unclear, as previous reviews have largely combined multimodal exercise interventions. Objective: To systematically review and meta-analyze the effects of isolated RT on peripheral BDNF levels in i...
Multiple Sclerosis
William Riciere Pedon, Gustavo De Conti Teixeira Costa, Lorenzo de Ávila Rodrigues Cortizo Vidal, Pedro Augusto Inacio, Marcelo Magalhães Sales, Ivanéria Mendonça Martins, James Oluwagbamigbe Fajemiroye, Sergio Machado, Vicente Aprigliano, Gabriela Ribeiro Inacio, Adolfo Mundombe Cameia, Gaspar R. Chiappa, Eduardo da Matta Mello Portugal, Alberto Souza Sá Filho•
In patients with ulcerative colitis (UC), primary sclerosing cholangitis (PSC) is one of the strongest risk factors for colorectal neoplasia. Although PSC affects only a minority of patients with inflammatory bowel disease, its coexistence with UC substantially alters the natural history of colorectal carcinogenesis. Evidence from Europe and North America has consistently shown that patients with concomitant PSC and UC develop colorectal neoplasia at a younger age, after a shorter disease durati...
Ulcerative colitis (UC) is a chronic inflammatory disease characterized by recurrent bleeding, diarrhea, and abdominal pain [1], with a disease course ranging from mild symptoms to severe, potentially life-threatening conditions such as acute severe UC [2]. Given this wide spectrum of disease severity, timely selection of an appropriate and effective therapy is crucial, particularly for patients with moderate-to-severe UC. The growing number of approved advanced therapies for UC has provided cl...
Abstract Objectives To describe the prescription patterns of second-line biological disease-modifying antirheumatic drugs (bDMARDs) in non-systemic juvenile idiopathic arthritis (JIA) and to assess the effectiveness of TNFα inhibitors (TNFi) versus non-TNFi as second-line bDMARDs. Methods This retrospective cohort study included patients with non-systemic JIA treated with at least two bDMARDs. Multivariate analyses were performed using logistic generalised estimating equations (GEE) models w...
Juvenile Idiopathic Arthritis
Marino A, Pellico MR, Conti EA, Rossano M, Lanni S, Germinario S, Amati A, Pandolfi M, Iannone C, Costi S, Baldo F, Gattinara MV, Minoia F, Filocamo G, Caporali R, Chighizola CB, Pediatric Rheumatology Associated Group of the Milan Area (PRAGMA)•
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