Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Cardiogenic shock (CS) complicating acute MI (AMI-CS) remains associated with high mortality and morbidity, despite advances in coronary revascularisation and mechanical circulatory support (MCS). Outcomes are determined not only by individual therapies, but also by the organisation of care, with current guidelines emphasising multidisciplinary, system-level approaches to enable rapid diagnosis, triage and treatment. This review examines how CS centres function within regional networks of care....
Cardiovascular
Jeyaprakash P, McGarvey M, Ansell E, Simpson R, Hamilton G, Alsinbili A, Mohamed M, Tindale A, Kalra S, Hill J, Price S, Perera D, Proudfoot A, Jain A, Khan SQ, Byrne J, MacCarthy P, Mariathas M, Johnson T, Rees P, Panoulas V, Davies J, Curzen N, Blackman D, Keeble TR, Pareek N•
Background: Plague, a paradigmatic zoonotic disease, depends on the intricate interplay among ecological environments, climatic conditions, and host-vector-pathogen interactions for its transmission. Climate change is reshaping the ecological distribution and transmission risks of plague. However, a systematic understanding of the future epidemiological trends for the Northern Tianshan Natural Plague Focus in Xinjiang remains limited. Methods: By employing an optimized maximum entropy model (Max...
Currently, there are still no reliable pre-treatment biomarkers for vedolizumab in ulcerative colitis. To investigate baseline mucosal signals, we reconstructed the discovery cohort from GSE73661 and evaluated the derived panel in the blood samples from GSE191328 and the independent mucosal RNA-seq cohorts from E-MTAB-7845. The reconstructed cohort comprised 24 baseline samples, including 14 composite responders and 10 non-responders. Through repeated LASSO variable selection, the study identifi...
Background: We aimed to establish thresholds for assessing clinically meaningful pain improvement after spinal injections using numerical rating scale (NRS) and patient-reported relative reduction (PRR) of pain. Methods: This single-center retrospective study included 1,828 patients who received spinal injections at our spinal intervention center and completed a 2-week follow-up telephone interview in 2017. NRS absolute and relative reductions were calculated using the NRS scores before injectio...
Pain
Yoonah Do, Wookon Son, Youngjune Kim, Choong Guen Chee, Yusuhn Kang, Eugene Lee, Yeo Ju Kim, Joon Woo Lee•
Background: On June 12, 2026, the US Food and Drug Administration (FDA) approved capivasertib (Truqap; AstraZeneca) in combination with abiraterone and prednisone for adult patients with metastatic androgen pathway modulation-naive or -sensitive (mAPMN/S) prostate cancer, corresponding clinically to metastatic hormone-sensitive prostate cancer (mHSPC), that is PTEN-deficient as detected by an FDA-authorized test. The pivotal CAPItello-281 trial demonstrated a statistically significant radiograph...
Chronic obstructive pulmonary disease (COPD) is a respiratory disease with a high degree of cellular heterogeneity and molecular complexity, characterized pathologically by persistent airflow limitation and an inflammatory-tissue remodeling cascade involving multiple cell types. Traditional transcriptomics lack the resolution to precisely define cell subpopulation roles in COPD. Single-cell RNA sequencing (scRNA-seq) overcomes this limitation by enabling high-resolution analysis of cell-type-spe...
Copd
Hong Jiang, Wenxing Wang, Lu Wang, Jiaojian Wu, Jianjiang Luo, Qi Yan, Xueli Gong, Jing Liang•
Background: Human antibiotic use is widely believed to contribute to the evolution and maintenance of antimicrobial resistance (AMR) in bacterial pathogens. While antibiotic stewardship should thus discourage use in situations where AMR-related harms outweigh clinical benefit, evidence to inform this assessment of tradeoffs is lacking, most notably in low-resource settings where gaps in antibiotic access persist. Quantitative understanding of use-resistance relationships is thus necessary as cou...
Antibiotic
Benjamin J. Singer, Alec Gleason, Isabella Impalli, Mikkel D. Nagorsen, Chungman Chae, Lauren C. Granskog, Philip C. Lee, Ramanan Laxminarayan, Joseph A. Lewnard•
Online handwriting provides a low-burden source of cognitive–motor measurements, but small datasets can yield optimistic results when preprocessing, task selection, or explanation is not separated from evaluation. We evaluated eight classifiers on the DARWIN dataset (174 participants; 25 tasks; 450 predictors) using ten repetitions of 5-outer/3-inner-fold nested stratified cross-validation. All preprocessing, hyperparameter selection, and calibration were restricted to outer training data. We ad...
Alzheimer’S Disease
Tehreem Fatima, Tahira Anwar Lashari, Momina Moetesum, Sana Anwar Lashari•
Background Plague, a paradigmatic zoonotic disease, depends on the intricate interplay among ecological environments, climatic conditions, and host-vector-pathogen interactions for its transmission. Climate change is reshaping the ecological distribution and transmission risks of plague. However, a systematic understanding of the future epidemiological trends for the Northern Tianshan Natural Plague Focus in Xinjiang remains limited. Methods By employing an optimized maximum entropy model (Ma...
Plague
Li F, Zhao G, Moming A, Liu X, Ma P, Zhan S, Wang H, Chen J, Tuerdali W, Wang Q, Luo T, Wu H, Zhang Y•
ABSTRACT Vehicle composition may influence topical corticosteroid performance. In two patients with disseminated granuloma annulare, switching from clobetasol ointment to the same‐strength solution in diethylene glycol monoethyl ether (DEGEE) was followed by complete clearance, suggesting formulation optimization may be considered when topical treatment provides an inadequate response.
The early stages of hip osteoarthritis (OA) remain less clearly defined, particularly regarding the optimal therapeutic interventions to slow or prevent disease progression. This review synthesizes current evidence on the diagnosis and management of early hip OA, with an emphasis on hip preservation techniques. Initial management typically involves conservative measures, including nonsteroidal anti-inflammatory drugs (NSAIDs), physical therapy, and corticosteroid injections. For select patients,...
Osteoarthritis
Lunn K, Huckleby J, Brown CL, Krakora E, Destine H, Vyas D, Hicks JJ•
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