Clinical intelligence & editorial.

PubMed

Autonomous digital lifestyle intervention for obesity: a comparative study of software-generated vs. provider-delivered body composition outcomes.

Background Many lifestyle intervention apps for weight management rely on human coaching, which increases cost and variability, or use calorie-counting approaches that lack structured, individualized guidance. Fully autonomous digital platforms that deliver personalized nutrition and exercise plans with body composition tracking remain limited. Objective To compare an autonomous, protein-focused digital lifestyle intervention (RightBMI App) with provider-delivered lifestyle intervention for w...

Body Composition

Pagani I, Syed M, Ages C, Bell M, Raftopoulos Y• October 23, 2026

PubMed

BSJPHXF modulates the FGF23-Klotho bone-kidney axis and calcium-phosphorus metabolism in ovariectomized rats with postmenopausal osteoporosis.

Objective To investigate the effects of the Kidney-Tonifying, Spleen-Strengthening and Blood-Activating Formula (BSJPHXF, also known as Gukang Formula) on the FGF23-Klotho bone-kidney axis and calcium-phosphorus metabolism in a rat model of postmenopausal osteoporosis. Methods Forty SPF female Sprague-Dawley rats were randomly divided into sham-operated, ovariectomized (OVX; model), BSJPHXF and Liuwei Dihuang Wan (LWDHW; positive control) groups (n=10 per group) and treated by gavage for 4 we...

Osteoporosis

Zhang H, Zhang Y, Ning B, Lin Y, Wang P, Zhang X, Guo Z, Zhu G• October 23, 2026

PubMed

Erratum: Expert consensus on vitamin D in osteoporosis.

In the published article entitled “Expert consensus on vitamin D in osteoporosis” (Ann Joint 2025;10:1. doi: 10.21037/aoj-24-48) (1), the funding information “and National Key Research and Development Program Project: Research on Health Intervention Technology for Construction Workers of High Altitude Ultra long Deep Buried Tunnels (No. 2021YFB2301703)” was inadvertently listed, which should be removed from this article. The Funding section should be corrected and updated as follows: Funding:...

Osteoporosis

Editorial Office• October 23, 2026

PubMed

Research progress on the mechanism of microglia-astrocyte signal crosstalk in central sensitization of vestibular migraine.

Vestibular migraine (VM) is a vestibular disorder characterized by recurrent episodes of vertigo, frequently accompanied by headache, nausea, and vomiting, which substantially reduce patients’ quality of life. The pathogenesis of VM remains incompletely understood. Current studies mainly focus on ion channel dysfunction, trigeminovascular mechanisms, and genetic susceptibility. Increasing evidence suggests that neuroinflammation and central sensitization play important roles in the onset and mai...

Migraine

Jin T, Wang W, Qin J, Liu Y, Fan X, Zhang D, Zhang H• October 23, 2026

PubMed

Dysregulation of the vaginal microbiota in endometriosis and impact of endocrine disruptors: an exploratory case-control study.

Background Endometriosis is associated with chronic inflammation and immune dysregulation, yet its relationship with the vaginal microbiota remains poorly characterized. Emerging evidence suggests that endocrine-disrupting chemicals (EDCs) may further contribute to microbial imbalance. This study aimed to (1) characterize and compare vaginal microbiota composition between women with endometriosis and healthy controls, and (2) investigate associations between vaginal microbial profiles and self-...

Endometriosis

Tricotteaux-Zarqaoui S, Kabbour M, Vandecandelaere A, Soudain M, Halbouty Z, Nadifi C, Cervino A, Cabry R, Bach V, Lahlou FA, Benkhalifa M, Khorsi-Cauet H• October 23, 2026

PubMed

Correlation between coagulation abnormalities and in vitro fertilization outcomes in infertile patients with endometriosis: a retrospective cohort study.

Objective To investigate coagulation function in infertile patients with endometriosis (EMs) undergoing IVF-ET and analyze its correlation with reproductive outcomes, providing evidence for perioperative optimization. Methods This retrospective cohort study included 216 infertile patients (108 with EMs, 108 age-matched tubal-factor controls) undergoing IVF-ET from 2022 to 2024. Only the first IVF cycle and first embryo transfer per patient were included in the primary analysis to ensure indep...

Endometriosis

Du X, Hu W, Fu C• October 23, 2026

PubMed

The dietary axis of endometriosis prevention: a gut microbiota-estrobolome framework situated within a multidimensional model of risk modification, early recognition, and disease management.

Endometriosis affects approximately 5%–10% of reproductive-aged women and imposes a substantial yet underexplored preventive research gap relative to treatment-focused literature. Diet is the central axis of this review: we organize the dietary evidence around an explicit mechanistic sequence—food-group-level epidemiological risk, hypothesised to be mediated by gut-microbiota dysbiosis and the estrogen-metabolizing “estrobolome”, and thence to candidate dietary and probiotic interventions—and th...

Endometriosis

Nagy S, Busznyák C, Dézsi C, Gulyás-Oldal V, Paschali E, Sallai D, Gálóczi I, Szili K• October 23, 2026

PubMed

COPD: real-world evidence on single-inhaler triple therapy and the emergence of biologic therapy.

Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide. Despite major pharmacological advances, a substantial gap persists between guideline recommendations and routine clinical practice, particularly after exacerbations. This narrative review summarizes current evidence supporting personalized pharmacological escalation in COPD, focusing on single-inhaler triple therapy (SITT) and the emergence of biologic therapy. SITT, combining an inhaled co...

Copd

Da Re B, Reccardini N, Monteleone G, Capparelli E, Hughes M, Bandini G, Wang Y, Confalonieri P, Salton F, Confalonieri M, Semenzato U, Ruaro B• October 23, 2026

PubMed

Correction: Low HDL cholesterol is associated with elevated TNFR1 and TNFR2 levels in early diabetic kidney disease.

In the published article, there was an error in the order of affiliation superscripts for the corresponding author “Xianhui Zhang”. Instead of “Xianhui Zhang¹,4*”, it should be “Xianhui Zhang4,¹*”. Affiliation 4 represents the primary institutional affiliation, while affiliation ¹ is the secondary affiliation. The full text of all affiliation descriptions remains unchanged. The original article has been updated.

Cholesterol

Su J, Su J, Wang W, Pan J, Zhang X• October 23, 2026

PubMed

Ultrasound guided intralesional injections of platelet rich plasma in the treatment of iliac crest pain syndrome and the associated low back pain.

Introduction Iliac Crest Pain Syndrome (ICPS) was established as a discrete and common cause for Low Back Pain (LBP) of soft tissue origin. Previous studies on ICPS proposed enthesopathy of Erector Spinae (ES) muscle and Thoracolumbar fascia (TLF) at the Posterior Super Iliac Spine (PSIS), as well as pathology of the Long Posterior Sacroiliac Ligament (LPSL) as main pathologic substrates in ICPS. Platelet rich plasma (PRP) is an orthobiologic treatment that was found to be especially efficaciou...

Back Pain

Todorov PT, Mekenyan L, Seventekidis L, Batalov A• October 23, 2026

PubMed

Penicillin Allergy Evaluation and Delabeling in Nursing Homes: An Implementation Science-Guided, Multi-stakeholder Qualitative Study.

Abstract Background Penicillin allergy labels (PALs) are common and often inaccurate, contributing to suboptimal antibiotic prescribing and adverse outcomes. These challenges are particularly pronounced in nursing homes (NH), where PAL prevalence and antibiotic exposure are high, yet penicillin allergy evaluation and delabeling are rarely implemented and stakeholder perspectives are poorly understood. We sought to identify barriers and facilitators to implementing penicillin allergy evaluation...

Allergy

Foong KS, LeClair AM, Alsoubani M, Doron S, Wurcel AG• October 23, 2026

PubMed

Growth trajectories in exclusively breastfed infants with clinically diagnosed food allergy: a prospective longitudinal cohort study.

Background Food allergy (FA) in infancy may be accompanied by feeding difficulties and dietary modifications during breastfeeding, which may influence early growth. However, longitudinal growth patterns in exclusively breastfed infants with clinically diagnosed FA remain incompletely characterized. Methods In this prospective longitudinal cohort study, 73 exclusively breastfed infants (30 with FA and 43 without FA) were enrolled at 4–6 months of age and followed through infancy. A total of 26...

Allergy

Fang J, Zhang Z, Zhong Y, Wan Y, Chen Q, Xia X, Zhang X• October 23, 2026