Silver Sulfadiazine (silver sulfadiazine)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Silver sulfadiazine is a synthetic anti-infective agent produced by the reaction of silver nitrate with sulfadiazine.
Silver sulfadiazine is used as an adjunct in the prevention and treatment of infection in second- and third-degree burns after resuscitative measures (including control of shock and pain, and correction of electrolyte imbalance) have been instituted. Because infection may extend tissue destruction beyond the burned area and may destroy epithelial islands that could initiate healing, control of bacterial growth may prevent the conversion of deep, partial-thickness wounds to full thickness. Concomitant administration of appropriate systemic anti-infective agents may be necessary if infection is present or suspected.
Generic name: silver sulfadiazine
Pronunciation: (SIL-ver SIL-fa-DYE-a-zeen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Silver Sulfadiazine
Indications
The following indications are listed for Silver Sulfadiazine:
- Infection Of Burn Wound
Also known as: Burn Wound Infection, Infected Burn Wound.
Dosing
Silver sulfadiazine, as a 1% cream, is applied topically to cleansed, debrided, burned areas once or twice daily using a sterile-gloved hand. The cream should be applied to a thickness of approximately 16 mm (one-sixteenth inch); the burned area should be covered with cream at all times. If necessary, the cream should be reapplied to any areas from which it has been removed by patient activity. If possible, the patient should be bathed daily to aid in debridement. Dressings are usually not required but may be used. Silver sulfadiazine cream should be applied to the burn wound as long as there is a possibility of infection, unless a clinically important adverse reaction occurs. Therapy is usually continued until healing is progressing well or until the site is ready for grafting.
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No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Reproduction studies in rabbits using silver sulfadiazine 3-10 times the usual human dosage have not revealed evidence of harm to the fetus. There are no adequate and controlled studies to date using silver sulfadiazine in pregnant women, and the drug should be used during pregnancy only when clearly needed. The drug is not recommended for use in pregnant women unless the burned area covers more than 20% of the body surface or the therapeutic benefits to the patient outweigh the possible risks to the fetus. Because sulfonamide therapy has produced kernicterus in neonates, silver sulfadiazine cream is contraindicated in pregnant women approaching or at term.
It is not known whether silver sulfadiazine is distributed into human milk. Because sulfonamides are distributed into milk and sulfonamides may cause kernicterus in infants younger than 2 months of age, silver sulfadiazine should be used with caution in nursing women.
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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