Drug class
Aminoglycosides, Parenteral
Parenteral aminoglycosides are a class of potent, intravenously or intramuscularly administered antibacterial agents—primarily including gentamicin, tobramycin, and amikacin—used for systemic therapy. Read more about Aminoglycosides, Parenteral
31 drugs in this class 23 manufacturers
Drugs in Aminoglycosides, Parenteral
GENTAMICIN SULFATE (gentamicin sulfate/PF)
AMIKACIN SULFATE
AMIKACIN (amikacin sulfate)
ZEMDRI (plazomicin sulfate)
ZEMDRI (plazomicin sulfate)
TOBRAMYCIN SULFATE
GENTAMICIN SULFATE
TOBRAMYCIN SULFATE
Parenteral aminoglycosides are a class of potent, intravenously or intramuscularly administered antibacterial agents—primarily including gentamicin, tobramycin, and amikacin—used for systemic therapy.
They exert concentration-dependent bactericidal action by crossing bacterial membranes and binding irreversibly to the 30S ribosomal subunit, which disrupts mRNA translation, causes mistranslation of proteins, and compromises the integrity of the bacterial cell envelope.
Clinically, these parenteral formulations serve as vital therapeutic options for severe, life-threatening systemic infections, including sepsis, complicated intra-abdominal infections, complicated urinary tract infections, hospital-acquired pneumonia, and infective endocarditis, predominantly targeting aerobic Gram-negative bacilli or working synergistically against select Gram-positive pathogens.
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nih.gov
Parenteral aminoglycosides are a class of potent, intravenously or intramuscularly administered antibacterial agents—primarily including gentamicin, tobramycin, and amikacin—used for systemic therapy They exert concentration-dependent bactericidal action by crossing bacterial membranes and binding irreversibly to the 30S ribosomal subunit, which disrupts mRNA translation, causes mistranslation of proteins, and compromises the integrity of the bacterial cell envelope Clinically, these parenteral ...
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nih.gov
Parenteral aminoglycosides are a class of potent, intravenously or intramuscularly administered antibacterial agents—primarily including gentamicin, tobramycin, and amikacin—used for systemic therapy They exert concentration-dependent bactericidal action by crossing bacterial membranes and binding irreversibly to the 30S ribosomal subunit, which disrupts mRNA translation, causes mistranslation of proteins, and compromises the integrity of the bacterial cell envelope Clinically, these parenteral ...
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nih.gov
They exert concentration-dependent bactericidal action by crossing bacterial membranes and binding irreversibly to the 30S ribosomal subunit, which disrupts mRNA translation, causes mistranslation of proteins, and compromises the integrity of the bacterial cell envelope
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