Antiarrhythmic - Class IB (Systemic)

Antiarrhythmic Class IB (Systemic) is a therapeutic category of cardiac medications that includes systemic agents such as lidocaine and mexiletine These drugs act by selectively binding and producing a mild, rapid-dissociation blockade of fast voltage-gated cardiac sodium channels, particularly in depolarized, ischemic, or rapidly firing myocardial tissue, which shortens the action potential duration and effective refractory period Clinically, systemic class IB agents are primarily indicated for...

Antiarrhythmic Class IB (Systemic) is a therapeutic category of cardiac medications that includes systemic agents such as lidocaine and mexiletine

These drugs act by selectively binding and producing a mild, rapid-dissociation blockade of fast voltage-gated cardiac sodium channels, particularly in depolarized, ischemic, or rapidly firing myocardial tissue, which shortens the action potential duration and effective refractory period

These drugs act by selectively binding and producing a mild, rapid-dissociation blockade of fast voltage-gated cardiac sodium channels, particularly in depolarized, ischemic, or rapidly firing myocardial tissue, which shortens the action potential duration and effective refractory period

Clinically, systemic class IB agents are primarily indicated for the acute suppression and chronic prevention of ventricular arrhythmias, notably ventricular tachycardia and ventricular fibrillation associated with myocardial infarction or cardiac ischemia, as well as selected congenital long QT syndromes