Antiarrhythmic - Class IC

Antiarrhythmic - Class IC is a therapeutic drug class under the Vaughan-Williams classification consisting of potent sodium-channel blockers, such as flecainide and propafenone.

These agents exert their primary electrophysiological effect by strongly inhibiting fast inward cardiac sodium currents with slow dissociation kinetics, significantly depressing phase 0 depolarization and slowing intracardiac conduction while having minimal effect on action potential duration.

Clinically, Class IC drugs are primarily utilized for the termination and rhythm-control maintenance of supraventricular arrhythmias, including atrial fibrillation, atrial flutter, and paroxysmal supraventricular tachycardias, as well as selected life-threatening ventricular arrhythmias in patients without structural or ischemic heart disease.