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Drug class

Antihistamines

Antihistamines are a broad pharmacological class of agents that inhibit the physiological actions of endogenous histamine by functioning primarily as inverse agonists or competitive antagonists at histamine receptors. Read more about Antihistamines

1,948 drugs in this class 271 manufacturers

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Drugs in Antihistamines

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About Antihistamines.

Antihistamines are a broad pharmacological class of agents that inhibit the physiological actions of endogenous histamine by functioning primarily as inverse agonists or competitive antagonists at histamine receptors.

The class is divided chiefly into histamine-1 receptor antagonists, which block peripheral and central histamine activity to mitigate allergic inflammation, and histamine-2 receptor antagonists, which suppress gastric acid secretion.

Clinically, these agents are widely utilized in allergy and immunology for conditions such as allergic rhinitis, urticaria, pruritus, and adjunct management of anaphylaxis, as well as in gastroenterology for peptic ulcer disease and gastroesophageal reflux disease.

Selected first-generation agents also provide secondary utility for motion sickness, vertigo, and mild insomnia due to their central nervous system penetration.